نتایج جستجو برای: neutrophil gelatinase associated lipocalin protein

تعداد نتایج: 2548891  

2014
Saverio Candido Roberta Maestro Jerry Polesel Alessia Catania Francesca Maira Santo S. Signorelli James A. McCubrey Massimo Libra

Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, there is a need to identify novel factors involved in cancer development and/or progression. Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014
María Teresa Torres-Salido Josefina Cortés-Hernández Xavier Vidal Anna Pedrosa Miquel Vilardell-Tarrés Josep Ordi-Ros

BACKGROUND One of the challenges of treating patients with lupus nephritis (LN) is to accurately assess disease activity and predict its outcome. Since renal-biopsy cannot be performed routinely, new surrogate biomarkers are needed. METHODS We evaluated neutrophil gelatinase-associated lipocalin (NGAL), to predict renal outcome in LN. Serum and urinary NGAL levels, measured by the enzyme-link...

Journal: :Journal of the American Society of Nephrology : JASN 2014
Steven G Coca Amit X Garg Heather Thiessen-Philbrook Jay L Koyner Uptal D Patel Harlan M Krumholz Michael G Shlipak Chirag R Parikh

Urinary biomarkers of AKI provide prognostic value for in-hospital outcomes, but little is known about their association with longer-term mortality after surgery. We sought to assess the association between kidney injury biomarkers and all-cause mortality in an international, multicenter, prospective long-term follow-up study from six clinical centers in the United States and Canada composed of...

Journal: :Circulation. Cardiovascular interventions 2015
Cristina Quintavalle Chiara Viviani Anselmi Francesca De Micco Giuseppina Roscigno Gabriella Visconti Bruno Golia Amelia Focaccio Bruno Ricciardelli Enzo Perna Laura Papa Elvira Donnarumma Gerolama Condorelli Carlo Briguori

BACKGROUND Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury (AKI). METHODS AND RESULTS Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, and 48 hours after contrast media (CM) exposure in 458 high-risk patients (development set). Optimal thresholds in predicting contrast-induced AKI (serum creatinine [sCr] increase ≥0.3 mg/dL at 48 hours a...

Ali Jahanian-Najafabadi Amaneh Mohammadi Roushandeh, Mahdi Rouhbakhsh Mahshid Mohammadi Pour Mehryar Habibi Roudkenar, Nasser Masroori Parisa Bahmani Raheleh Halabian

Objective(s) Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-associated(NGAL) in insect cells was the aim of this study. Materials and M...

2015
Giovanni De Caridi Mafalda Massara Francesco Spinelli Raffaele Grande Lucia Butrico Pierandrea Rende Maurizio Amato Rita Compagna Bruno Amato Stefano de Franciscis Raffaele Serra

The association of an axillary artery aneurysm and an abdominal aortic aneurysm is extremely rare. In this study, we describe this association in a 69 year-old-man. We measured this patient's metalloproteinases (MMPs) and Neutrophil Gelatinase - Associated Lipocalin (NGAL) levels over a three years period before the abdominal aortic aneurysm rupture. We speculate that high serium levels of MMPs...

Journal: :Blood purification 2010
Barbara Lisowska-Myjak

Acute kidney injury (AKI) is a frequent clinical problem in critically ill patients and the associated mortality is high. Standard serum and urine biomarkers are insensitive and nonspecific for the detection of kidney injury in its early stages which limits the therapeutic options and may compromise the outcome. The study presents new candidates for biochemical markers of AKI, with potentially ...

Journal: :The Biochemical journal 2005
Zhimin Tong Xuli Wu Dmitriy Ovcharenko Jiuxiang Zhu Ching-Shih Chen James P Kehrer

NGAL (human neutrophil gelatinase-associated lipocalin) and its mouse analogue 24p3 are members of the lipocalin family of small secreted proteins. These proteins are up-regulated in a number of pathological conditions, including cancers, and may function as transporters of essential factors. Although previous publications have suggested that 24p3 has pro-apoptotic functions, other data are mor...

Journal: :The Annals of thoracic surgery 2014
Amber O Molnar Chirag R Parikh Steven G Coca Heather Thiessen-Philbrook Jay L Koyner Michael G Shlipak Mary Lee Myers Amit X Garg

BACKGROUND Acute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature. METHODS We conducted a multicenter prospective cohort study of 625 adult patients undergoing elective c...

Journal: :American journal of physiology. Renal physiology 2016
Richard A Zager Ali C M Johnson Kirsten Frostad

α1-Microglobulin (A1M) is a low-molecular-weight heme-binding antioxidant protein that is readily filtered by the glomerulus and reabsorbed by proximal tubules. Given these properties, recombinant A1M (rA1M) has been proposed as a renal antioxidant and therapeutic agent. However, little direct evidence to support this hypothesis exists. Hence, we have sought "proof of concept" in this regard. C...

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