Natsume Fusanosuke is one of the founding critics manga that pioneered a style formal analysis in 1990s. Natsume’s first important foray into his “theory expression” (hyōgenron) was seen collaborate work, Manga no yomikata (How to read manga) 1995. He later streamlined those ideas twelve-episode series wa naze omoshiroi ka: sono bunpō hyōgen (Why so interesting?: Its grammar and expression) for...

Too often in the field of computer graphics, practitioners have been more concerned with the question of how to move a camera rather than why to move it. This thesis addresses the core question of why the camera is being placed and moved and uses answers to that question to provide a more convenient, more intelligent method for controlling virtual cameras in computer graphics. After discussing ...

Natural disasters kill people and damage the place where people live. The people of the damaged district have to evacuate to a safe zone. Foreigners who use different languages have difficulty to acquire information about disaster and evacuation guide. However, Japanese government offers disaster prevention and situation for foreigners who are not good at Japanese language. Tohoku earthquake an...

Housekeeping (HK) genes fulfill the basic needs for a cell to survive and function properly. Their ubiquitous expression, originally thought to be constant, can vary from tissue to tissue, but this variation remains largely uncharacterized and it could not be explained by previously identified properties of HK genes such as short gene length and high GC content. By analyzing microarray expressi...

We show that, by combining an existing compression boosting technique with the wavelet tree data structure, we are able to design a variant of the FM-index which scales well with the size of the input alphabet Σ. The size of the new index built on a string T [1, n] is bounded by nHk(T )+O ( (n log log n)/ log|Σ| n ) bits, where Hk(T ) is the k-th order empirical entropy of T . The above bound h...

Glycoproteins and non-glycoproteins possessing unfolded/misfolded parts in their luminal regions are cleared from the endoplasmic reticulum (ER) by ER-associated degradation (ERAD)-L with distinct mechanisms. Two-step mannose trimming from Man9GlcNAc2 is crucial in the ERAD-L of glycoproteins. We recently showed that this process is initiated by EDEM2 and completed by EDEM3/EDEM1. Here, we cons...

Retro-translocation from the ER to the cytosol of proteins within the secretory pathway takes place on misfolded molecules that are targeted for degradation by the cytosolically located 26S proteasome complex. Retro-translocation occurs also for other proteins (such as calreticulin) that, despite being synthesized and transported to the ER, are in part dislocated to the cytosol. We have taken a...

Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse co...

AAA BBB CCC DDD EEE FFF GGG HHH III JJJ KKK LLL MMM NNN OOO PPP HGB GHA FED EFC DCF CDE BAH ABG POJ OPI NML MNK LKN KLM JIP IJO KJD LIC ILB JKA ONH PMG MPF NOE CBL DAK ADJ BCI GFP HEO EHN FGM MIE NJF OKG PLH IMA JNB KOC LPD EAM FBN GCO HDP AEI BFJ CGK DHL OFL PEK MHJ NGI KBP LAO IDN JCM GND HMC EPB FOA CJH DIG ALF BKE PCN ODM NAP MBO LGJ KHI JEL IFK HKF GLE FIH EJG DOB CPA BMD ANC BDC ACD DBA C...

MicroRNAs (miRNAs) are epigenetic regulators of eukaryotic gene expression and play key roles in many cellular processes. However, the role of miRNAs for replicative senescence of normal human keratinocytes (NHKs) remains unknown. Thus, we examined the expression profiles of 847 miRNAs in exponentially replicating and senescent NHKs and identified 126 senescence-associated miRNAs (SA-miRs). Amo...