Four novel oxapenem compounds (i.e., AM-112, AM-113, AM-114, and AM-115) were investigated for their beta-lactamase inhibitory activity against a panel of isolated class A, C, and D enzymes, which included expanded-spectrum beta-lactamase enzymes (ESBLs). The oxapenems were potent beta-lactamase inhibitors. Activity varied within the group, with AM-113 and AM-114 proving to be the most active c...

This article presents an integrated multi-criteria decision making using Entropy, MOORA and COPRAS methods for turning Nimonic C263. Experiments were performed under L27 Taguchi orthogonal array. Dry was cubic boron nitride (CBN) used to turn the alloy. The variables speed, feed depth of cut chosen as factors. For each experiment, shear force component measured during on line. insert flank wear...

West Syndrome is characterized by infantile spasms, a hypsarrhythmic electroencephalogram (EEG) pattern, and a poor neurodevelopmental prognosis. First-line treatments include adrenocorticotrophic hormone (ACTH) and vigabatrin, but adverse effects often limit their use. CPP-115 is a high-affinity vigabatrin analogue developed to increase therapeutic potency and to limit retinal toxicity. Here, ...