A 25-year-old woman in the 7th month of pregnancy was operated upon for a ruptured cerebral aneurysm. Sodium nitroprusside was used to achieve effective controlled hypotension. Signs of foetal distress were transient. Subsequent delivery was spontaneous and uneventful. Development of the child at 2 yr was satisfactory. The various physiological aspects and the action of nitroprusside on both mo...

Left ventricular pressure and segment length were measured in seven conscious chronically instrumented dogs with the pericardium intact and 3-9 days after pericardiectomy. Diastolic pressure-length plots were obtained under control conditions and after acute volume loading followed by sodium nitroprusside infusion. In all dogs with intact pericardium, volume loading displaced the entire diastol...

We have studied the effect of intraperitoneal nitroprusside on small (urea) and middle (vitamin B12) molecule dialysis clearances in patients maintained on chronic peritoneal dialysis. Clearances were measured in six patients during the addition of 6 mg of nitroprusside to three and seven consecutive, hourly two-liter exchanges during the course of a routine dialysis treatment. Results indicate...

We studied 11 patients with congestive heart failure and 10 normal volunteers for in vivo platelet aggregate formation activity. The patients with heart failure had significantly (p < 0.01) more circulating platelet aggregates than the normal volunteers. During sodium nitroprusside infusion, the number of circulating platelet aggregates declined to normal levels and in vitro platelet aggregatio...

Background: Computational modeling of physiology has become a routine element in the development, evaluation, and safety testing many types medical devices. Members Food Drug Administration have recently published manuscript detailing validation, sensitivity computational model for blood volume, cardiac stroke pressure, noting that such might be useful development closed-loop fluid administrati...

Endothelial dysfunction is important in the pathophysiology of preeclampsia. No study has examined endothelial function sequentially at different gestations before development of the clinical syndrome and after delivery (to compare maternal from placental influences). We sought to determine whether endothelial function changes before the clinical development of preeclampsia. We measured skin mi...