Insoluble, inactive inclusion bodies are frequently formed upon recombinant protein production in transformed microorganisms. These inclusion bodies, which contain the recombinant protein in an highly enriched form, can be isolated by solid/liquid separation. After solubilization, native proteins can be generated from the inactive material by using in vitro folding techniques. New folding proce...

As part of the current research programme these laboratories are investigating the synovia of normal and abnormal human joints by light and electron microscopy. By synovia is meant the material lining joints and tendon sheaths on the interior of the fibrous capsule, including, therefore, synovial cells, loose connective tissue, blood vessels, and inflammatory cells which may be present. Several...

PURPOSE OF REVIEW Inclusion body myositis (IBM) is a poorly understood progressive muscle disease of middle and later life. Its dual pathologies of autoimmunity and unexplained myofiber degeneration and loss have been enigmatic since its earliest descriptions over 40 years ago. No reliable effective therapy currently exists for IBM. This review provides an update of current issues in the pathog...

this study compared the use of five different models to describe the growth from birth to 20 weeks of age of kids from both genders of nondescript goats. fifty nine (59) nondescript kids were weighed weekly at the university of maiduguri livestock teaching and research farm, nigeria and the live weights were modeled. biologically relevant variables were estimated for each kid from the logistic,...

Inclusion body myositis (IBM) was first identified as a specific disorder about 40 years ago and is now recognized to be the most frequently presenting primary myopathy in middle age and beyond. Initial characterization was based on the observation of specific pathological features distinguishing it from polymyositis. It was soon appreciated that there were also distinguishing clinical features...

Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regar...