We scrutinize three decades of probability density displacement distribution in a simple colloidal suspension with hard-sphere interactions. In this index-matched and density-matched solvent, fluorescent tracer nanoparticles diffuse among matrix particles that are eight times larger, at concentrations from dilute to concentrated, over times up to when the tracer diffuses a few times its size. D...

Matrix tablets were prepared using blends of xanthan gum (XG), Guar gum (GG) and ethylcellulose (EC). The polymers were combined using six different ratios; 1:1:1, 1:2:1, 1:2:2, 2:2:1, 2:1:2 and 2:1:1 to produce formulations XG1GG1EC1, XG1GG2EC1, XG1GG2EC2, XG2GG2EC1. XG2GG1EC2 and XG2GG1EC1 respectively. Metronidazole was used as the model drug. The ability of the prepared matrices to target d...

Nizatidine is a gastroprotective drug with short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, E4M, K15 K200M. Directly compressed revealed an excellent uniformity in hardness, thickness weight was evenly distributed within the matrix tablets. Buoyancy lag time as low 18–38 s, rem...

the aim of this study is to formulate a novel ophthalmic nanosuspension (ons), an alternative carrier system to traditional colloidal carriers for controlled release (cr) of acyclovir (acv). in the present study, ons is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

Objective(s): Pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. Researchers have intended to reformulate drugs so that they may be more safely used in human body. The more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. The aim of t...

A mathematical method called subordination broadens the applicability of the classical advection--dispersion equation for contaminant transport. In this method, the time variable is randomized to represent the operational time experienced by different particles. In a highly heterogeneous aquifer, the operational time captures the fractal properties of the medium. This leads to a simple, parsimo...

The long-term limit motions of individual heavy-tailed (power-law) particle jumps that characterize anomalous diffusion may have different scaling rates in different directions. Operator stable motions [Y(t):t> or =0] are limits of d-dimensional random jumps that are scale-invariant according to c(H)Y(t)=Y(ct), where H is a dxd matrix. The eigenvalues of the matrix have real parts 1/alpha(j), w...

In this study, matrix-type transdermal patches of glibenclamide were developed using a combination hydrophilic and hydrophobic polymers for investigating the efficacy carriers. A cellulose derivative, HPMC E50, was used as matrix-forming polymer, Eudragit RS 100 polymer. The solvent casting technique employed to develop blend patch formulation chloroform methanol solvent. No drug–polymer intera...