The fragile X mental retardation protein (FMRP) plays a role in the control of local protein synthesis in the dendrites. Loss of its production in fragile X syndrome is associated with transcriptional dysregulation of the gene. Recent work demonstrates that Sp1 and NRF1 transcriptionally control this gene. Other studies reveal how the microRNA pathway and signaling are related to FMRP function ...

With the development of power system interconnection, the low-frequency oscillation is becoming more and more prominent which may cause system separation and loss of energy to consumers. This paper presents an innovative robust control for power systems in which the operating conditions are changing continuously due to load changes. However, practical implementation of robust control can be fra...

In various studies of sporadic breast cancers, 40-70% were strongly positive for fragile histidine triad (Fhit) protein expression, whereas only 18% of BRCA2 mutant breast cancers demonstrated strong Fhit expression, suggesting that the BRCA2 repair function may be necessary to retain intact fragile common chromosome fragile site 3B(FRA3B)/FHITloci. In the current study, 22 breast tumors with d...

Fragile X syndrome, the most common form of hereditary mental retardation, causes disruption in the development of dendrites and synapses, the targets for axonal growth in the central nervous system. This disruption could potentially affect the development, wiring, and targeting of axons. The current study utilized diffusion tensor imaging (DTI) to investigate whether white matter tract integri...

The viscosity of glass formers increases by several orders of magnitude upon cooling near the glass transition temperature. For strong glass formers, this increase is Arrhenius-like, that is, the viscosity increases exponentially with inverse temperature, whereas, for fragile glass formers, this increase is super-Arrhenius-like. Recent experimental and theoretical evidence indicates that fragil...

When multiple robots collaboratively transport or manipulate a load, both motion and force need to be considered. This is especially true when the load is fragile or needs to be moved rapidly. Tight force coordination is possible if all robots share their force information and the grasp geometry is completely known. When this is not the case, a common approach is to use the leader/follower stra...

OBJECTIVE The purpose of this study was to determine if children with fragile X syndrome, who typically demonstrate a neurobehavioral phenotype that includes social anxiety, withdrawal, and hyper-arousal, have increased levels of cortisol, a hormone associated with stress. The relevance of adrenocortical activity to the fragile X phenotype also was examined. METHOD One hundred and nine childr...

Males with fragile X syndrome (FXS) have difficulties with social interaction and many show autistic features. This study examined whether the social deficits characteristic of FXS are associated with theory of mind difficulties. Two groups of boys with FXS participated: a group with few autistic features and a group with many autistic features. An intellectual disability control group also par...

Thirteen species of benthic marine algae are reported new for the isolated mid-Atlantic Azores archipelago and five older records are confirmed. Seven (Bangia atropurpurea, Codium fragile spp. tomentosoides, Ectocarpus fasciculatus, E. siliculosus, Porphyrostromium ciliare, Ulothrix flacca and Ulvaria oxysperma) are widespread amphi-Atlantic species some of which extend in distributional range ...