BACKGROUND Depression worsens the prognosis in patients with cardiac disease, and treatment with antidepressants may improve survival. Guidelines recommend use of selective serotonin reuptake inhibitors (SSRIs), but knowledge of the prognostic effect of different classes of antidepressants is sparse. METHODS AND RESULTS We studied 99 335 patients surviving first hospitalization for heart fail...

BACKGROUND Effects of beta-blockers on the prognosis of the heart failure patients with preserved ejection fraction (HFpEF) remain controversial. The aim of this meta-analysis was to determine the impact of beta-blockers on mortality and hospitalization in the patients with HFpEF. METHODS A search of MEDLINE, EMBASE, and the Cochrane Library databases from 2005 to June 2013 was conducted. Cli...

Abstract Background In heart failure with mildly reduced ejection fraction (HFmrEF) European guidelines recommend the use of antineurohormonal therapies a low level evidence (IIb C) based on data from subgroup and post-hoc analyses randomized clinical trials (RCTs). Data large unselected real-world HFmrEF populations are lacking. Purpose To assess association between renin-angiotensin system in...

OBJECTIVES The purpose of this research was to explore the prospective relationship between the use of beta-blockers and depression in myocardial infarction (MI) patients. BACKGROUND Beta-blocker use has been reported to be associated with the development of depression, but the methodological quality of studies in this field is weak. METHODS In a multicenter study, MI patients (n 127 non–beta-b...

OBJECTIVES The goal of this study was to evaluate the mortality benefit of beta-blockers after successful percutaneous coronary intervention (PCI). BACKGROUND Beta-blockers reduce mortality after myocardial infarction (MI), though limited data are available regarding their role after successful PCI. METHODS Each year from 1993 through 1999, the first 1,000 consecutive patients undergoing PC...

Background: Overdoses with cardiovascular drugs are related with significant morbidity and mortality. Beta-adrenergic blockers, calcium-channel blockers (CCBs), thiazide, digoxin and angiotensin converting enzyme (ACE) inhibitors represent five of the most important classes of cardiovascular drugs. Overdoses with cardiovascular drugs are typically caused by exploratory ingestion by children or ...

BACKGROUND Endothelial dysfunction (ED) frequently precedes cardiovascular diseases (CVD) and is a well-established risk factor of major adverse cardiac events. Beta-blockers are the fundamental drugs used in CVD treatment. METHODS A systematic literature search for randomized controlled trials investigating influence of beta-blockers on endothelial function assessed by flow-mediated dilation...

Objective: The study was conducted to identify the prescribing practices in essential hypertension to find out prescribing patterns in elderly patients. Material and methods: A retrospective study was done to assess the pattern and prescription of antihypertensive drugs at Maharishi Markandeshwar Medical College and Hospital, Kumarhatti Solan (H.P) A total of 100 handwritten prescriptions of pa...

After the results of first multicenter, prospective randomized clinical trial (RCT) evaluating long-term efficacy oral beta-blockers in patients with preserved left ventricular ejection fraction (LVEF) after ST elevation myocardial infarction (STEMI), we decided to conduct an updated systematic review and meta-analysis evaluate beta-blocker use LVEF who underwent percutaneous coronary intervent...