In advanced metastatic melanoma (non-resectable stage III/IV), the prognosis still remains poor, with median survival times between six and twelve months. Systemic therapeutic approaches for metastatic melanoma include chemotherapy, immunotherapy, immunochemotherapy, small molecules and targeted therapy. In this review, we will focus on the various treatment modalities as well as new agents use...

Screening behavior depends on previous screening history and family members' behaviors, which can act as both confounders and intermediate variables on a causal pathway from screening to disease risk. Conventional analyses that adjust for these variables can lead to incorrect inferences about the causal effect of screening if high-risk individuals are more likely to be screened. Analyzing the d...

This paper develops a search model to explain the long tail effect. Search targetibility or the quality of search is explicitly modeled. Consumers are searching for the right products within the right categories. Mainstream consumers are distinguished from long tail consumers in terms of the prevalence of consumer tastes in the population. We show that mainstream consumers enjoy higher utility ...