Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse ...

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the leading causes of hepatic fibrosis liver-related mortality worldwide, despite efficient hepatitis B C antiviral therapies that have dramatically lowered load. Although significant efforts been exerted to understand molecular basis pathogenesis, there currently few therapeutic alternatives available for NAFL...

This study was conducted to analyze the change in intestinal flora of patients with nonalcoholic steatohepatitis and its correlation to the levels of the inflammatory cytokines interleukin-10 (IL-10) and IL-17. We selected 90 patients that were diagnosed with and treated for nonalcoholic steatohepatitis as the patient group and 80 healthy cases as the control group. We then compared the intesti...

Background & AimsNonalcoholic steatohepatitis (NASH) is associated with an increase in healthcare resource use and poor health-related quality of life (HRQoL). We assessed the humanistic economic burden NASH, disease management, patient journey.MethodsWe performed a cross-sectional analysis data, collected from July through November 2017, Growth Knowledge Disease Atlas Real-World Evidence progr...