Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we report that in Saccharomyces cerevisiae, loss of mtDNA leads to nuclear genome instability, through a process of cell-cycle arrest and selection we define as a cellular crisis. This crisis is not mediated by the absence of respiration, but ...

Congenital lipoid adrenal hyperplasia (CLAH) is caused by mutations to the steroidogenic acute regulatory protein (StAR) gene associated with the inability to synthesize all adrenal and gonadal steroids. Inadequate treatment in an infant with this condition may result in sudden death from an adrenal crisis. We report a case in which CLAH developed in Korean siblings; the second child was prenat...

We analyze the multifractal spectra of daily foreign exchange rates for Japan, Hong-Kong, Korea, and Thailand with respect to the United States in the period from 1991 until 2005. We find that the return time series show multifractal spectrum features for all four cases. To observe the effect of the Asian currency crisis, we also estimate the multifractal spectra of limited series before and af...

This study examines the productivity and resilience of agroecosystems in the Korean Peninsula. Having learned valuable lessons from a Chapman University project funded by the United States Department of Agriculture which concentrated on the semi-arid region of southwestern United States, our joint Korea—Chapman University team has applied similar methodologies to the Korean Peninsula, which is ...

This paper illustrates how nuclear crisis are managed in France. It proposes IT solutions dedicated to event management that could help to resolve such a crisis by facilitating coordination between actors and increasing situational awareness. This study has been conducted as part of the European project PLAY. Requirements have been collected from different stakeholders through reviews of the li...

The paper discusses the impact and implications of Korean unification by setting up a two-region endogenous growth model. The numerical solutions are based on the formal analytical model, and have been calibrated so that they reflect the observed features of the North and South Korean economies. The numerical solutions provide evidence about the speed of convergence and the large amount of inte...

BACKGROUNDS This study examines social inequalities in life expectancy and mortality during the transition period of the Korean economic crisis (1993-2010) among Korean adults aged 40 and over. METHODS Data from the census and the national death file from the Statistics Korea are employed to calculate life expectancy and age-specific-death-rates (ASDR) by age, gender, and educational attainme...

1. Khang YH. Two Koreas, war and health. Int J Epidemiol 2013;42:925–29. 2. Shin S. Two Koreas and public health: ‘First, do no harm’. Int J Epidemiol doi:10.1093.ije/dyu014 3. Goodkind D, West L, Johnson P. A Reassessment of Mortality in North Korea, 1993–2008. Available at: http://paa2011. princeton.edu/papers/111030 (17 December 2013, date last accessed). 4. Spoorenberg T, Schwekendiek D. De...

The red fox (Vulpes vulpes) is the most widely distributed terrestrial carnivore in the world, occurring throughout most of North America, Europe, Asia, and North Africa. In South Korea, however, this species has been drastically reduced due to habitat loss and poaching. Consequently, it is classified as an endangered species in Korea. As a first step of a planned red fox restoration project, p...

Dear Editor, The big public health concern in this year is the nuclear crisis in Japan that causes contamination of nuclides around the world. The effect of the exposure to leaked nuclides from the present nuclear crisis on reproductive health is a topic to be concerned. In my previous publication (1), the evidence on the relationship between nuclear exposure and infertility can be confirmed. H...