AIM To evaluate the efficacy of nortriptyline (NOR) added to a multi-component smoking cessation intervention, which included cognitive-behavioural therapy (CBT) and provision of nicotine replacement therapy (NRT). DESIGN Randomized controlled trial (RCT) comparing two study groups with blinded follow-up at 3, 6 and 12 months. Both groups received a multi-component smoking cessation intervent...

the objective of the present study was to prepare controlled release formulation of moxifloxacin hydrochloride ocular nanoparticles. the nanoparticles were prepared by solvent displacement method using eudragit rl 100 as a polymer. different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. the formulations were evaluated i...

Literature survey reveals that few analytical methods were reported for the estimation of cinacalcet hydrochloride by LC, UV methods. Hence the present study aims in developing simple, rapid, precise and validated methods for cinacalcet hydrochloride in bulk. The methods are Colorimetric determination of Cinacalcet Hydrochloride by Visible Spectrophotometric method, Validation of Cinacalcet Hyd...

A four-coordinate, sixteen-electron Ru(0) complex containing the tetradentate diamino-diolefin ligand (±)-trans-N,N-bis(5H-dibenzo[a,d]cyclohepten-5-yl)-1,2-diaminocyclohexane (trop2dach) has been synthesised. Deprotonation of one amino N-H functional group generates an unprecedented four-coordinate ruthenate species which has been characterised in solution and in the solid state. The newly for...

Abstract: Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine has been hindered for long time due to its poor solubility low bioavailability. This study aims design liposomes-gel enhance bioavailability activity hydrochloride. Materials Metho...

background: a simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma. methods: the mobile phase composed of acetonitrile-water 60:40 (v/v) and 0.2% formic acid 20 µl of sample was chromatographically analyzed using a repacked zorbax-xdb-ods c18 column (2.1 mmx30...

introduction: many studies have revealed that drug addicted individuals exhibit impaired performance on executive function tests but a few studies have been conducted on executive functions of drug addicts in iran. to contribute to this understanding, the present study was designed to assess some domains related to executive functions including cognitive flexibility, attention and speed of ment...