Volume 18, Issue 2 November 2002

Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the selenenyl iodide intermedi...

Carbajal, José M., and Richard C. Schaeffer, Jr. RhoA inactivation enhances endothelial barrier function. Am. J. Physiol. 277 (Cell Physiol. 46): C955–C964, 1999.—The modulation of endothelial barrier function is thought to be a function of contractile tension mediated by the cell cytoskeleton, which consists of actomyosin stress fibers (SF) linked to focal adhesions (FA). We tested this hypoth...

HIROYASU TSUKAGUCHI,1 STANISLAWA WEREMOWICZ,2 CYNTHIA C. MORTON,2 AND MATTHIAS A. HEDIGER2,3 1Membrane Biology Program and Renal Division, Department of Medicine, and 2Departments of Pathology and Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital and Harvard Medical School, and 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Bo...

Volume 19, Issue 2 November 2003

In the US alone, roughly 1.4 million patients undergo operations requiring arterial prosthesesannually (1). Tissue engineering (TE) represents a potential means to construct functional small diametervascular grafts in situations where autologous tissue is unavailable and conventional synthetic materials fail.While initial results with many of the TE vascular grafts (TEVGs) construct...

Kita, Toshihiro, Kazuo Kitamura, Junichiro Sakata, and Tanenao Eto. Marked increase of guanylin secretion in response to salt loading in the rat small intestine. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G960–G966, 1999.—Guanylin and uroguanylin are intestinal peptides that stimulate guanylate cyclase C and cause chloride secretion. These peptides show topological instability due t...

Electrokinetic techniques continue to play a leading role in technologies ranging from nanoparticle characterization and directed electronics assembly to micropumps and micromixers to biosensors and DNA sequencing. In this session, we invite submissions related to the development of new technologies in any of these areas, from both the fundamental and applied perspectives. Suitable topics inclu...