Conventional basal insulin preparations have to be resuspended prior to injection and have low therapeutic efficacy and drawbacks like nocturnal hypoglycaemia. There is evidence supporting improved pharmacokinetic and pharmacodynamic profiles of basal insulin analogues, glargine and detemir as compared with NPH. Initiation and titration of basal insulin analogues helps patients to improve compl...

We aimed to investigate the effect of carbohydrate counting on metabolic and clinical parameters in patients with type 1 diabetes mellitus (DM) who were on flexible multiple daily insulin therapy. Nine volunteer adolescent patients using intensive insulin treatment (short acting insulin before meal plus two doses of long acting insulin (NPH) per day) were enrolled in the study. Clinical and met...

INTRODUCTION AND OBJECTIVE The costs of the insulin analogue (insulin glargine) have been growing appreciably in the State of Minas Gerais in Brazil, averaging 291% per year in recent years. This growth has been driven by an increasing number of successful law suits and a 536% price difference between insulin glargine and neutral protamine Hagedorn (NPH) insulin. One potential way to address th...

OBJECTIVE Because there are limited data on the comparison of insulin aspart and mixed insulin in type 2 diabetes, this trial was performed to compare the efficacy and safety of preprandial insulin aspart with human soluble insulin (HI) and human premix (70% NPH/30% regular) insulin (MIX). RESEARCH DESIGN AND METHODS A total of 231 type 2 diabetic patients were randomized to insulin aspart (n...

OBJECTIVE This study aimed to compare the glucose-lowering effect and glycemic variability of insulin glargine with those of insulin detemir. MATERIAL AND METHODS This was an open-label, single-center, randomized, two-way crossover study in patients with diabetes on basal-bolus insulin therapy, with neutral protamine Hagedorn (NPH) insulin as basal insulin. Patients switched from NPH insulin ...

BACKGROUND Blood glucose control is fundamental albeit not enough to prevent diabetic macrovascular complications. Dipeptidyl peptidase-4 (DPP-4) inhibitors are effective in improving metabolic parameters in patients with type 2 diabetes mellitus (T2DM) but little is known about its cardiovascular effects. We compared the DPP-4 inhibitor sitagliptin with bedtime NPH insulin (NPH) as add-on ther...

BACKGROUND Decision-makers have begun to recognize Health-Related Quality of Life (HRQoL) as an important and measurable outcome of healthcare interventions; and HRQoL data is increasingly being used by policy-makers to prioritize health resources. Our objective was to measure HRQoL in a group of Type 2 Diabetes Mellitus (T2DM) patients receiving insulin treatment in Buenos Aires, Argentina. ...