AIM Sequence analysis and phylogenetic studies based on non-structural protein-3 (NS3) gene are important in understanding the evolution and epidemiology of bluetongue virus (BTV). This study was aimed at characterizing the NS3 gene sequence of Indian BTV serotype-2 (BTV2) to elucidate its genetic relationship to global BTV isolates. MATERIALS AND METHODS The NS3 gene of BTV2 was amplified fr...

Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 August 2022 on 182 who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals Medan, Indonesia. The...

Background: Human Givens (HG) Rewind is a relatively unknown trauma-focussed treatment. This paper aimed to provide preliminary evidence of the effectiveness treat posttraumatic stress (PTS) in variety clinical settings Great Britain. Methods: An observational prospective design was used each four studies. Standardised questionnair...

Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and associated with neuroinflammation neuropsychiatric disorders, including disruption of sleep/wake patterns, now recognised as a circadian disorder. traditionally studied using murine models infection due to lack alternative in vitro</ns3:it...

Background Changes in blood transcript abundance levels have been associated with pathogenesis a wide range of diseases. While next generation sequencing technology can measure on genome-wide scale, downstream clinical applications often require small sets genes to be selected for inclusion targeted panels. Here we set out gather information from the l...

Background: The aim of this study was to perform a comparative evaluation 5% Sodium fluoride varnish, neutral nano silver (NSF) varnish and acidulated in remineralising artificially induced enamel caries primary teeth. Methods: 39 anterior teeth were sectioned 2mm below the cemento-enamel junction (CEJ) mounted acrylic resin blocks...

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution ...

Background: HIV/AIDS is still a major public health issue around the world, especially in Sub-Saharan Africa (SSA), where this has resulted unquantifiable human suffering, social and cultural disruption, enormous economic losses. Methods: This study aims to assess women’s knowledge attitude toward its prevention Ghana.<ns3:...

Many viral proteins undergo proteolytic processing events that are required for virus infection and virion assembly. In this issue of Biochemical Journal, Strongin and co-workers report that the NS3 protease from West Nile virus unexpectedly cleaves certain substrates at pairs of basic residues, a specificity that resembles that of the furin-like PCs (proprotein convertases). This led to the de...

Background: Reactive oxygen species and other free radicals, together with glucose its metabolites are believed to play important roles in the aging process. The carbohydrate components of glycosylated proteins mediating cell-cell interactions a role has been suggested for them Erythrocytes critical cells human body, heavily relatively easily available so good candid...