INTRODUCTION: The nipple-sparing mastectomy (NSM) improves aesthetic results after breast reconstruction through preservation of the entire skin envelope, obviating the need for reconstruction of the nipple areola complex (NAC). NSM, however, is associated with a higher risk for occult pathology and skin necrosis, which can require resection and compromise the reconstructive outcome. In DIEP fl...

We identify Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) as a novel component of neuronal synapses whose absence increases dendritic spine size and filamentous actin levels in an N-WASP/Arp2/3-independent, RhoA/ROCK/profilinIIa-dependent manner. These effects depend on the reduction of membrane sphingomyelin (SM) due to transcriptional upregulation of neutral sphingomyelina...

Fiber-reinforced polymers (FRPs) have been widely utilized to improve the seismic performance of deficient reinforced concrete (RC) columns. In recent years, one of the emerging types of FRPs used is basalt fibers. In this study, the performance of existing columns was experimentally examined before and after applying near-surface mounted (NSM) basalt FRP (BFRP) rebars as a retrofitting techniq...

BACKGROUND AND PURPOSE The Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) established guidelines to increase safety in acute stroke thrombolysis, but precluding treatment in an important proportion of patients. We aimed to assess safety/efficacy of thrombolysis in patients with SITS-MOST exclusion criteria. METHODS 369 nonlacunar tPA-treated patients were studied. ...

In sea urchin embryos Delta signaling specifies non-skeletogenic mesoderm (NSM). Despite the identification of some direct targets, several aspects of Delta Notch (D/N) signaling remain supported only by circumstantial evidence. To obtain a detailed and more complete image of Delta function we followed a systems biology approach and evaluated the effects of D/N perturbation on expression levels...

We wanted to determine whether the production of endogenous nitric oxide (NO) is affected by cigarette smoking and various pathological conditions. Endogenously produced NO was measured by chemiluminescence in the exhaled air of 81 healthy volunteers (21 nonsmoking females (NSF), 12 smoking females (SF), 24 nonsmoking males (NSM) and 24 smoking males (SM)) and 38 patients (10 with hypertension,...

BACKGROUND The simple and well-described structure of the C. elegans nervous system offers an unprecedented opportunity to identify the genetic programs that define the connectivity and function of individual neurons and their circuits. A correspondingly precise gene expression map of C. elegans neurons would facilitate the application of genetic methods toward this goal. Here we describe a pow...

• Since Wilkie’s result [9] (which established that the elementary theory Texp of (R, exp) is model complete and o-minimal), many o-minimal expansions of the reals have been investigated. The problem of constructing nonarchimedean models of Texp (and more generally, of an ominimal expansion of the reals) gained much interest. • In [2] it was shown that fields of generalized power series cannot ...

We introduce and analyse a new class of graphs called SM-sum graphs. This has been done by using the concept that any positive integer can be expressed as a sum of powers of 2. This relation between powers of 2 and other positive integers are very much used in Computer Science especially in the binary number system, bit string operations, in signal processing etc. We are making use of this rela...