Neurotensin (NT) increases neurotransmission within the mesolimbic dopamine system by enhancing the firing rate of dopaminergic (DAergic) neurons and by acting at the nerve terminal level. The signal transduction pathways involved in these effects have not been characterized, but NT receptors are coupled to the phospholipase C pathway and Ca(2+) mobilization. However, an enhancement of intracel...

Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT; LANT-6) are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this pa...

BACKGROUND Recently, we synthesized a nonviral gene vector capable of transfecting cell lines taking advantage of neurotensin (NT) internalization. The vector is NT cross-linked with poly-L-lysine, to which a plasmid DNA was bound to form a complex (NT-polyplex). Nigral dopamine neurons are able to internalize NT, thus representing a target for gene transfer via NT-polyplex. This hypothesis was...

background: stem cells from human exfoliated deciduous teeth (shed) have the capability to differentiate into neural cells. neurotrophins including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), and neurotrophin-4 (nt-4) have neurogenesis, neurotrophic, or neuroprotective effects and are expressed in developing teeth. the aim of this study was to mea...

lack of sufficient information on conservation tillage systems leads to the dominating use of conventional tillage practice in most parts of iran. testing other management practices may help in decision making regarding the types of tillage systems that reduce soil deterioration. a three- years field experiment was conducted to study the effects of conventional (ct), reduced (rt) and no-till (n...

BACKGROUND The value of routine aminoterminal pro type B natriuretic peptide (NT-proBNP) measurements in outpatient clinics remains unknown. OBJECTIVES We sought to determine the accuracy with which heart failure (HF) specialists can predict NT-proBNP levels in HF outpatients based on clinical assessment. METHODS We prospectively studied 160 consecutive HF patients followed in an outpatient...

Neurotrophin-6 (NT-6) was identified in the teleost fish Xiphophorus as a new member of the neurotrophin gene family. NT-6 binds specifically the glycosaminoglycan heparin. In this study NT-6 was expressed in a stably transfected mammalian cell line, and in insect cells via a recombinant baculovirus. It was purified to homogeneity and characterized by MS and N-terminal sequencing. NT-6 from bot...

Recently, the conception rates after artificial insemination have been pointed out to decline continuously. To overcome this problem, the control of frozen and thawed sperm quality is required. However, the mechanism of bovine sperm functional regulation is still largely unknown. In mammals, the ejaculated sperm are capable of showing fertilizing ability during migration in the female reproduct...