nucleotides

The synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - CP bond in place of the 5' -COP bond of the naturally occuring nucleotides is described. The preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -D-ribofuranosyl pyrimidines to the corresponding 1-? -D-arabinofuranosyl pyrimidines are also explained

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Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension

Journal: :Nucleic Acids Research 2021

Abstract Nonenzymatic copying of RNA templates with activated nucleotides is a useful model for studying the emergence heredity at origin life. Previous experiments defined-sequence have pointed to poor fidelity primer extension as major problem. Here we examine mismatches during on random in simultaneous presence all four 2-aminoimidazole-activated nucleotides. Using deep sequencing approach t...

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Mosaic organization of DNA nucleotides.

Journal: :Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics 1994

C K Peng S V Buldyrev S Havlin M Simons H E Stanley A L Goldberger

Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range po...

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