Introduction: Sleepiness may predispose drivers to road traffic accidents. Obstructive Sleep Apnea Syndrome is the most common medical cause of sleepiness. Hence increased neck circumference (NC) and obesity are known as obstructive sleep apnea syndrome risk factors. This study was conducted to assess OSAS role in occurrence of road traffic accidents in sleeping drivers of commercial heavy veh...

We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken from patients di...

OF DOCTORAL THESIS TESTOSTERONE AND CORTISOL IN OBSTRUCTIVE SLEEP APNEA (OSA) SYNDROME SCIENTIFIC COORDINATOR PROF. DR. TRAIAN MIHĂESCU

Complex regional pain syndrome (CRPS) is evoked by conditions that may be associated with local and/or systemic inflammation. We present a case of long-standing CRPS in a patient with Ehlers-Danlos syndrome in which prolonged remission was attained by directing therapy toward concomitant small intestinal bacterial overgrowth, obstructive sleep apnea, and potential increased microglia activity. ...

Obesity hypoventilation syndrome (OHS) is defined as obesity (body mass index, >30 kg/m2) with daytime hypoventilation (PCO2, >45 mmHg) that is not secondary to cardiopulmonary or neurologic disease. Around 80–90% of the patients with OHS have obstructive sleep apnea and severe arterial oxygen desaturation. Obstructive sleep apnea has been found to be associated with a variety of eye diseases, ...

A 58-year-old woman presented with slowly-progressive lower limb weakness. Medical history disclosed a six-year history of obstructive sleep apnea syndrome (OSAS). Examination disclosed abnormal tongue features (Figure 1) and proximal flaccid tetraparesis. Muscle MRI showed marked compromise of the adductor magnus, and muscle biopsy disclosed vacuolar myopathy with PAS-positive vacuoles (Figure...

INTRODUCTION Obstructive sleep apnea is defined as repetitive (≥5/hour) partial or complete cessation of breathing during sleep. Whereas obstructive sleep apnea is often considered to be associated with sexual problems in men, studies concerning effects of obstructive sleep apnea on female sexual function and distress are sparse. AIM To investigate sexual dysfunction and sexual distress in fe...

Ten patients with autonomic nervous system dysfunction (familial dysautonomia, juvenile diabetes, or Shy-Drager syndrome) were studied to assess the impact of their impairment on breathing during sleep. Several types of breathing dysfunction during sleep were identified independent of the patients' primary complaints. Obstructive sleep apnea syndrome was the most common; central sleep apnea and...

OBJECTIVE Obstructive sleep apnea is common among patients with hypertrophic cardiomyopathy and may contribute to poor cardiovascular outcomes. However, obstructive sleep apnea is largely unrecognized in this population. We sought to identify the clinical predictors of obstructive sleep apnea among patients with hypertrophic cardiomyopathy. METHODS Consecutive patients with hypertrophic cardi...

In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of cytochrome P4502D6 (CYP2D6). We now report 3 additional fatal or life-threatening cases from North America. In the 2 fatal cases, functional gene duplications encoding for CYP2D6 caused a significantly greater product...