Keratitis-Ichthyosis-Deafness syndrome is a rare congenital disorder of the ectoderm caused by mutations in the connexin-26 gene (GJB2) on chromosome 13q11-q12, giving rise to keratitis, erythrokeratoderma and neurosensory deafness. We report the case of a 31-year-old black male diagnosed as having KID syndrome. Sequencing analysis showed a heterozygous missense mutation D50N (148G > A) in the ...

The chemotactic activity of normal human polymorphonuclear leukocytes (PMNs) confronted with heat inactivated sera from patients with psoriasis as well as various chronic proliferative diseases was determined using modified Boyden chambers. By the addition of phorbol myristate acetate (PMA) at a concentration of 1 ng/ml the chemoattractant activities of the sera were greatly potentiated. Howeve...

CMAJ • APRIL 19, 2011 • 183(7) © 2011 Canadian Medical Association or its licensors E430 Acne vulgaris has a substantial impact on a patient’s quality of life, affecting both self-esteem and psychosocial development.1 Patients and physicians are faced with many over-the-counter and prescription acne treatments, and choosing the most effective therapy can be confusing. In this article, we outlin...

In an inherited genetic hypersensitivity, normai levels of androgens may cause cosmetic disturbances or even dermatologica! diseases: acne and alopecia. The cosmetic dermatologist is called for help. Androgenetic stimulation leads to increased levels of sebum, to an imbalance of lipids on the skin surface, to follicular hyperkeratosis and, finally, to the fonnation of comedones. In those patien...

Lucent Cracks of Heavens: Maciej Kazimierz Sarbiewski, Stars and an “Etrurian Poet” The paper tries to display the links between a catalogue metaphors contained in Sarbiewski’s handbook entitled Characteres lyrici, seu Horatius et Pindarus Giambattista Marino’s Canzone delle stelle. Based upon his college lectures (Połock 1626/1627), work offers practical rules for composition lyrical poetry so...

La maladie de Hoffman ou perifolliculitis capitis abscedens et suffodiens dite cellulite disséquante du cuir chevelu est une cause rare d'alopécie cicatricielle, faisant partie des folliculites décalvantes. Il s'agit d'une suppuration profonde chronique, non infectieuse, dont l'étiologie est inconnue atteignant préférentiellement les hommes entre 20 et 40 ans, noirs dans 80% des cas. Les lésion...

In 1987, Chamot et al attempted to unify the various descriptions of osteoarticular disease associated with skin manifestations into a syndrome with the acronym SAPHO: synovitis, acne, pustulosis, hyperostosis, and osteitis (Chamot et al., 1987). Furthermore, the clinical feature of aseptic chronic recurrent multiple osteomyelitis (CRMO) accompanied by pustulosis with its typical presentation i...

INTRODUCTION Treatment of the severe forms of acne vulgaris remains a challenge. Isotretinoin is a drug often used in these cases. Retinoids affect the mechanisms that play a role in the pathogenesis of acne, reduce the production of sebum and sizes of the sebaceous glands. However, isotretinoin appears to have undesirable side effects in the skin, mucous membranes and hair. AIM THE AIM OF TH...