Background: Histological and histometrical effects of Fennel Essential Oil (FEO) on ovary structure were studied during postnatal development in female wistar rats. Materials and Methods: For this purpose, the female rats, after parturition divided in control, sham and experimental groups with equal number of female pups for each mother at random. Sham 1 and experimental 1 groups consisted of m...

Excessive exposure to alcohol prenatally has a myriad of detrimental effects on the health and well-being of the offspring. It is unknown whether chronic low-moderate exposure of alcohol prenatally has similar and lasting effects on the adult offspring's health. Using our recently developed Sprague-Dawley rat model of 6% chronic prenatal ethanol exposure, this study aimed to determine if this m...

Infants who are passively exposed to morphine or heroin through their addicted mothers usually develop neurobiological changes. The postsynaptic density 95 (PSD-95) protein, a submembranous cytoskeletal specialization, is dynamically linked with N-methyl-d-aspartate receptors (NMDARs) to form a synaptic complex in postsynaptic neurons. This complex serves important neurobiological functions, in...

Animal studies have shown that prenatal stress is able to induce long-lasting neurobiological and behavioral alterations in adult offspring. In spite of the facts that hippocampus is sensitive to early developmental influences and its known functional importance in learning and memory, few data are available on the effect of prenatal stress on the structure of hippocampus. Therefore, this study...

The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, duri...

Hypertension is common and contributes, via cardiovascular disease, towards a large proportion of adult deaths in the Western World. High salt intake leads to high blood pressure, even when occurring prior to birth - a mechanism purported to reside in altered kidney development and later function. Using a combination of in vitro and in vivo approaches we tested whether increased maternal salt i...

Epidemiological and experimental studies report associations between overweight mothers and increased obesity risk in offspring. It is unclear whether neonatal leptin regulation mediates this association between overweight mothers and offspring obesity. We investigated the effect of neonatal treatment with a leptin antagonist (LA) on growth and metabolism in offspring of mothers fed either a co...

Research demonstrated that folate deficiency in either the mother or father could impact biological functions of offspring’s neural cells. Folate can also impair methionine cycle, thus contributing to conversion S-adenosylmethionine (SAM) S-adenosylhomocysteine (SAH), which potentially cause damage central nervous system. The study focused on effect parental cell apoptosis offspring neonatal ra...

Bonzi is a new plant growth regulator containing the active ingredient paclobutrazol of triazole chemical class. for use on ornamental plants, such as Chrysanthemum, Perennial Plants, Bedding Foliage Geraniums, Hibiscus and Azaleas, in nurseries greenhouses.
 
 VKM was requested by Norwegian Food Safety Authority to consider potential induce reproductive effects humans; particular rel...

Transcription Activator-Like Effector Nucleases (TALEN) are potential tools for precise genome engineering of laboratory animals. We report the first targeted genomic integration in the rat using TALENs (Transcription Activator-Like Effector Nucleases) by homology-derived recombination (HDR). We assembled TALENs and designed a linear donor insert targeting a pA476T mutation in the rat Glucocort...