BACKGROUND The fructus of Kochia scoparia Schrader (Chenopodiaceae) is a traditional herbal medicine that has been used for treating gonorrhea and dermatitis. OBJECTIVE We investigated the anti-inflammatory activities of three marker compounds, including 20-hydroxyecdysone, momordin Ic, and oleanolic acid, from the fructus of K. scoparia. MATERIALS AND METHODS The simultaneous analysis of t...

Using the bioresources of Regional Specialised Collection Alkanotrophic Microorganisms (acronym IEGM, Perm, Russia; WFCC # 285), R. rhodochrous IEGM 757 was selected, which catalyzed C5, C22, and C23 functionalization pentacyclic triterpenoid oleanolic acid (OA, 3?-hydroxyolean-12-en-28-oic acid, 1.0 g/L) to form a new 5?,22?-dihydroxy derivative gypsogenic (3?,5?,22?-trihydroxyolean-12-ene-23,...

The title compound, C(37)H(50)N(2)O(3), is a benzyl ester derivative of oleanolic acid, a penta-cyclic triterpene, with a five-membered oxadiazole ring fused to the ring A. The triterpene A and C rings adopt slightly distorted half-chair conformations, whereas the remaining three six-membered rings are in chair forms.

OBJECTIVES Previous study has demonstrated that oleanolic acid (OA) possessing the anti-inflammatory and antioxidant properties, blunted high glucose induced diabetic cardiomyopathy, and ameliorated experimental autoimmune myocarditis in mice. However, little is known about its effects on pressure overload induced cardiac remodeling. Herein, we investigated the effect of OA on cardiac remodelin...

Health threat due to snake bite is one of the most ignored areas of active research vis-à-vis other domains of human healthcare studies. Fatalities due to snake bite are a major health threat affecting the lives of thousands of people every year in many developing countries. The prevalence of mortality caused by snake bite is taken as one of the serious challenges to solve the problem. The obje...