Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease, which have no any effective treatment method. There are various pathophysiological processes underlying the disease such glial neurotrophic support. There is no cure yet for ALS but there are many clinical trials that focused different therapeutic targets. One of the most popular treatment methods is cell transplantation...

BACKGROUND Stroke and traumatic injury to the nerve system may trigger axonal destruction and the formation of scar tissue, cystic cavitations and physical gaps. Olfactory ensheathing cells (OECs) can secrete neurotrophic factors to promote neurite growth and thus act as a prime candidate for autologous transplantation. Biological scaffolds can provide a robust delivery vehicle to injured nerve...

Olfactory ensheathing cells (OECs) prepared from the olfactory bulbs of adult transgenic Sprague Dawley (SD) rats expressing green fluorescent protein (GFP) were transplanted into a dorsal spinal cord transection lesion of SD rats. Five weeks after transplantation, the cells survived within the lesion zone and oriented longitudinally along axons that bridged the transection site. Although the h...

(2015) Harvesting of olfactory ensheathing cells for autologous transplantation into the spinal cord injury. Its complexity in dogs. The mucosa lining the nasal cavity and its content contains olfactory sensory neurons (OSNs). The OSNs are organized into different territories (four in mammals with a more sophisticated model) and, with the exception of the OSNs enclosed in the vomeronasal organ,...

During development of the primary olfactory system, axon targeting is inaccurate and axons inappropriately project within the target layer or overproject into the deeper layers of the olfactory bulb. As a consequence there is considerable apoptosis of primary olfactory neurons during embryonic and postnatal development and axons of the degraded neurons need to be removed. Olfactory ensheathing ...

BACKGROUND The failure of regeneration after spinal cord injury (SCI) has been attributed to axonal demyelination and neuronal death. Cellular replacement and white matter regeneration are both necessary for SCI repair. In this study, we evaluated the co-transplantation of olfactory ensheathing cells (OEC) and embryonic stem (ES) cell-derived motor neurons (ESMN) on contused SCI. METHODS OEC ...

Temporal and spatial localization of nerve growth factor receptor (p75NGFR) in the developing olfactory system and gonadotropin-releasing hormone-1 (GnRH) system was characterized and its role analyzed using p75NGFR null mice and nasal explants. Prenatally, p75NGFR was expressed by GnRH neurons and olfactory ensheathing cells (OECs). In p75NGFR null mice, no change in the number of GnRH cells w...