Sex hormone binding globulin (SHBG) is involved in delivering sex hormones to target tissues. We investigated the association between the (TAAAA)n repeat polymorphism, and Asp327Asn polymorphism in the SHBG gene with semen quality and idiopathic male infertility. We studied 168 men with idiopathic infertility [oligoasthenoteratozoospermia (OAT)] and equal number of age-matched normal controls. ...

3003 Reported relationship between increased CTG repeat lengths in myotonic dystrophy and azoospermia Dear Sir, We read with interest the analysis by Pan and colleagues. in which they conclude that, in the myotonic dystrophy protein kinase (DMPK) variable CTG repeat region, alleles of 18 or more repeat units are observed only in patients with non-obstructive azoospermia and not in controls (Pan...

IVF has become a well-established treatment for certain types of infertility, including long-standing infertility due to tubal disease, endometriosis, unexplained infertility or infertility involving a male factor. Soon it became clear that certain couples with severe male-factor infertility could not be helped by conventional IVF. Extremely low sperm counts, impaired motility and/or abnormal m...

OBJECTIVE To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones. PATIENTS AND METHODS The FSH-R polymorphisms at codons 680 and 307 were analysed by restriction-fragment-length polymorphism (RFLP) in 172 infertile men and in an equal num...

Abstract Study question Does blastocysts’ iDAScore® differs when ICSI is performed instead of IMSI in case teratozoospermia on the day vitro fertilization (D0)? Summary answer Blastocysts’ unchanged or at (D0). What known already In routine practice, for D0-teratozoospermia sometimes not because its higher cost and/or laboratory workload. Time-Lapse studies have shown that (IVF) using suboptima...

Abstract Study question Investigating estradiol in relation with other sperm parameters might reveal new correlations which would help our understanding of male idiopathic infertility Summary answer Statistical significance was found a series E2 levels and sperm, hormonal health What is known already Male rising major concern, counts decreasing by 50-60% the recent decades. The causes for are v...

mega-3 fatty acids found in some foods have a wide-range of health benefits. The omega-3 supplementation results in higher antioxidant activity in human seminal fluid and enhanced sperm count, sperm motility, and sperm morphology. Considerable number of infertile men with idiopathic oligoasthenoteratozoospermia might be benefit from omega-3 fatty acids administration. Infertility caused by idio...

INTRODUCTION Infertility or sterility or barrenness is defined as a state of inability to conceive after a year of unprotected intercourse. Ovulation problems, uterine tube problems, endometriosis, uterine etiology problems, chromosomal problems which are not so rare, spermatogenesis disorders and azoospermia are stated as the most common causes of infertility. OBJECTIVE Main objective of thi...

BACKGROUND To develop and validate a simple and reliable high performance liquid chromatographic (HPLC) method for the analysis of free L-carnitine in human seminal plasma and to investigate its clinical significance as a potentially additional means of evaluating the infertile male. METHODS After proteins in seminal plasma are precipitated with a mixture of acetonitrile and methanol (9:1; v/...

Background: Fertilization is a multistep process requiring spermatozoa with unique cellular structures and numerous germ cell-specific molecules that function in the various steps. In the highly coordinated process of male germ cell development, RNA splicing and polyadenylation help regulate gene expression to ensure formation of functional spermatozoa. Male germ cells express tauCstF-64 (Cstf2...