Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as "pyrin domain-containing protein 3". The NLRP3 inflammasome is associated with onset and progression of various ...

celiac disease is characterized by a gluten-induced damage of the small bowel in sensitive individuals that may cause malabsorption. non-intestinal inflammatory diseases may trigger immunologic gluten intolerance in susceptible people and the hcv virus may be considered as a suitable candidate. interferon therapy could precipitate symptom onset in subjects with silent celiac disease. in fact, s...

Center for Inflammatory Bowel Diseases; Division of Digestive Diseases, David Geffen School of Medicine, The University of California Los Angeles, Los Angeles, CA Corresponding author: Hon Wai Koon, Ph.D. Center for Inflammatory Bowel Diseases, MRL 1519, 675 Charles E. Young Drive South, The University of California Los Angeles, Los Angeles, CA 90095, U.S.A. Tel: 310-825-9742 Email: hkoon@medne...

Gastrointestinal (GI) diseases, such as inflammatory bowel diseases (IBD), can manifest themselves with intestinal and extra-intestinal symptoms. Among the latter, cutaneous manifestations, such as pyoderma gangraenosum (PG) and metastatic Crohn's disease (MCD), represent a possible onset of IBD, with or without simultaneous bowel alterations. In such cases, intestinal and skin lesions are supp...

Sulphasalazine, one of the 5-amino-salicylates, is widely used for the treatment of inflammatory bowel diseases and arthritis. Among the reported adverse effects are blood dyscrasias and hepatic failure. Peripheral neuropathy has been reported as a rare adverse drug reaction to sulphasalazine. Most reported patients developed symptoms several weeks after onset of treatment. We describe a patien...