Current evidence indicates that dysregulation of the host inflammatory response to infectious agents is central to the mortality of patients with sepsis. Strategies to block inflammatory mediators such as PAF have been investigated as adjuvant therapies for sepsis. PAF-AH, the enzyme responsible for PAF degradation, showed positive results in pre-clinical studies and phase II clinical trials, b...

BACKGROUND Transvenous pacemaker implantation in dogs is associated with a relatively high complication rate. At our institution, pacemaker implantation in dogs with high-grade atrioventricular block (HG-AVB) frequently is performed as an after-hours emergency. HYPOTHESIS Among dogs with HG-AVB, the rate of major complications is higher when pacemakers are implanted after hours (AH) compared ...

i ntroduction: assessment of cellular cytotoxicity is a regular method for evaluating the biocompatibility of novel materials. in a recent study, 5% fluoride varnish (duraflur) has shown reasonable sealing ability and coverage of root canal walls when used as a sealer. the aim of the present study was to compare cytotoxicity of duraflur varnish with two popular commonly used root canal sealers ...

PURPOSE To determine whether myocilin is present in the aqueous humor (AH) and to examine certain properties of this protein. METHODS Human AH was obtained at the time of either glaucoma surgery or cataract extraction. Monkey AH was obtained at the time of death, and bovine aqueous was obtained from eyes delivered from an abattoir. Column chromatography was performed on aqueous samples to det...

Fetal grafts of the anterior hypothalamus (SCN/AH) containing the suprachiasmatic nucleus (SCN) restore circadian rhythms to SCN-lesioned host hamsters and rats following implantation into the third ventricle. Previous studies suggest that intraventricular SCN/AH grafts are variable in their attachment sites, the extent of their outgrowth, and the precise targets innervated in the host brain. H...

OBJECTIVES Accidental hypothermia (AH) is a potentially life-threatening condition that can lead to significant morbidity and life-long effects. Navy personnel are always at a greater risk of AH due to frequent outdoor work, wilderness exposure, prolonged immobility and exhaustion. The purpose of the survey was to assess Chinese Navy members' awareness of AH and to make recommendations with reg...

INTRODUCTION Both admission hyperglycemia (AH) and diabetes mellitus adversely affect the prognosis in acute coronary syndromes. We prospectively assessed the predictive role of AH in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS Three hundred-one consecutive patients hospitalized for STEMI were enrolled. Patients were stratified into four groups based on the...

BACKGROUND Platelet-activating factor (PAF) is a highly potent phospholipid mediator responsible for the life-threatening manifestations of anaphylaxis. PAF acetylhydrolase (PAF-AH) inactivates PAF and protects against severe anaphylaxis whereas deficiency of PAF-AH predisposes to severe or fatal anaphylaxis. Determinants of PAF-AH activity have not been studied in patients with peanut allergy....

Aromatic hydrocarbon (AH) effects are mediated by binding of the AH receptor and its heterodimeric partner aromatic hydrocarbon nuclear translocator to specific response elements on DNA (AHREs). CYP1A2 expression is induced by AHs, yet AHREs have been identified in CYP1A2 genes of only two species and their functional role assessed only in the human gene. There have been few analyses of CYP1A2 ...

Sažetak Arterijska hipertenzija (AH) jedan je od najvažnijih sprečivih (preventabilnih) uzroka prijevremenog umiranja i jedan od najvećih javnozdrastvenih problema današnjice u svijetu. Prevalencija AH je veća nego ranije i kreće se oko 40% u odraslim populacijama europskih zemalja, dok je u Sjedinjenim Američkim Državama značajno niža. Prema rezultatima studije “Epidemiologija arterijske hiper...