BACKGROUND Thimerosal is a preservative commonly used in ophthalmic solutions, otic drops, and vaccines because of its bactericidal property. OBJECTIVE To report a case of a generalized reaction to thimerosal in a patient who received an influenza vaccine. METHODS We describe a patient who developed a generalized maculopapular eruption after receiving a thimerosal-containing influenza vacci...

Prolonged far red irradiation of imbibed lettuce seeds (Lactuca sativa L. cv. Grand Rapids) makes them unresponsive to subsequent treatment with gibberellin. It has been found that this effect is overcome by supplying gibberellin buffered at a low pH. On the basis of this and other evidence it is suggested that an extended far-red exposure causes a loss of gibberellin sensitivity through an eff...

Sphingopyxis macrogoltabida strain 203, the type strain of the species, grew on polyethylene glycol (PEG) and has been deposited to the stock culture at the Biological Resource Center, National Institute of Technology and Evaluation (NITE), under the number NBRC 15033. Here, we report the complete genome sequence of strain NBRC 15033. Unfortunately, genes for PEG degradation were missing.

BACKGROUND The Canadian-accredited post-baccalaureate Doctor of Pharmacy program at Qatar University trains pharmacists to deliver advanced patient care. Emphasis on acquisition and development of the necessary knowledge, skills, and attitudes lies in the curriculum's extensive experiential component. A campus-based oral comprehensive examination (OCE) was devised to emulate a clinical viva voc...

The complete genome sequence of Sphingopyxis terrae strain 203-1, which is capable of growing on polyethylene glycol, was determined. The genome consisted of a chromosome with a size of 3.98 Mb and a plasmid with a size of 4,328 bp. The strain was deposited to the National Institute of Technology and Evaluation (Tokyo, Japan) under the number NBRC 111660.

Moxifloxacin and gatifloxacin are fourth-generation fluoroquinolone antibiotics used in the clinic to prevent or treat ocular infections. Their pharmacokinetics in the cornea is usually measured from extracted ocular fluids or tissues, and in vivo direct measurement is difficult. In this study multiphoton microscopy (MPM), which is a 3D optical microscopic technique based on multiphoton fluores...

Tell, G . P., Pasternak, G . W. & Cuatrecasas, P. (1975) FEBS Lett. 51, 242-245 Traber, J., Fischer, K., Latzin, S. & Hamprecht, B. (1974) FEBS Lert. 49, 260-263 Traber, J., Fischer, K., Latzin, S. & Hamprecht, B. (1975a) Nature (London) 153,120-122 Traber, J. , Gullis, R. & Hamprecht, B. (19756) Life Sci. 16, 1863-1868 Villarreal, J. E., Martinez, J. N. & Castro, A. (1977) Reported to the Comm...

IT is widely accepted that the physiological activity of alkaloidal eye preparations results from the penetration through the cornea of the free base portion rather than of the ionic form of the alkaloid (Cogan and Kinsey, 1942; Cogan and Hirsch, 1944; Swan and White, 1942). Therefore, the smaller the pKb value of the alkaloid, the fewer free base particles will be available for drug action at ...

PURPOSE The purpose of this study was to investigate the efficacy and safety of the administration of retinol palmitate (VApal) ophthalmic solution (500 IU/mL) for the treatment of patients with dry eye. PATIENTS AND METHODS This study included 66 patients with dry eye. After a 2-week washout period, patients were randomized (1:1) into either a VApal ophthalmic solution or a placebo group, an...