The endogenous central nervous tissue substance called MLC (morphine-like compound) is shown to bind to the opiate receptors of the mouse neuroblastoma X glioma hybrid cell line NG108-15. The interaction of MLC with these opiate receptors is noncooperative, as is the interaction of morphine, naloxone, and Leu-enkephalin with these receptors. A specific antibody to morphine will bind MLC but wil...

BACKGROUND The safety of opiate use for patients with Crohn's disease (CD) has long been a concern. The recent Crohn's therapy, resource, evaluation, and assessment tool (TREAT) registry update has added to these concerns by demonstrating an association of opiate use with an increased risk of infection and death in CD. While the association is clear, the relationship of opiates to these negativ...

65 The decreased sensitivity to clonidine would appear to be an important and reversible sign of withdrawal in the guinea-pig ileum. Such interactions between opiate receptors and a-adren-ergic receptors do not appear to occur in the mouse vas deferens (Gillan et al., 1979). However, vasa deferentia from rats treated chronically with clonidine showed lower sensitivity to the inhibitory effects ...

OBJECTIVE To investigate the effect of opiate substitution treatment at the beginning and end of treatment and according to duration of treatment. DESIGN Prospective cohort study. Setting UK General Practice Research Database. PARTICIPANTS Primary care patients with a diagnosis of substance misuse prescribed methadone or buprenorphine during 1990-2005. 5577 patients with 267 003 prescriptio...

The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (mu, morphine; kappa, dynorphin; delta, methionine enkephalinamide; sigma, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally...

Detoxification, the initial step in the treatment of opiate dependence (Freedman, 1980) has been facing difficulties in our country as the widely used drug methadone is not available. Earlier practices were either abrupt withdrawal or gradual tapering of the dose of the opiate to which the individual was dependent. Recently clonidine has been used with success for detoxification and treatment o...

background; methadone maintenance therapy (mmt) is an evidence-based approach for opiate addiction treatment. while its effectiveness in reducing opiate use has been evidently verified, unanswered questions with respect to the cultural scenarios for mmt programs remain unanswered. this study was conducted to explore understanding address mmt initiation among a women-recruited sample of persons ...

background: the common detoxification method is replacement of long effect opiate by short effect opiate and then reducing its amount gradually. more modern method is ultra rapid opiate detoxification (urod) by opiate antagonists, which is performed by general anesthesia. the advantages of two methods have not been confirmed. this study aimed to compare effectiveness and withdrawal rate in both...

BACKGROUND Although evidence points to a strong link between illicit drug use and crime, robust evidence for temporal order in the relationship is scant. We carried out a systematic review to assess the evidence for pathways through opiate/crack cocaine use and offending to determine temporal order. METHODS A systematic review sourced five databases, three online sources, bibliographies and c...

Ongoing studies from our group support the existence and biological importance of a distinct cellular signaling pathway involving endogenously synthesized, chemically authentic, l-morphine, its cognate mu(3) opiate receptor subtype, and constitutive NO synthase. Based on prior studies indicating evolutionary conservation and adaptation of morphinergic/NO-coupled signaling to mediate autocrine/p...