Individualization of acute postoperative pain treatment on an evidence-based decision process is a major health concern. The aim of this study is to investigate the influence of genetic and non-genetic factors on the variability of response to morphine in acute postoperative pain. A group of nighty-five patients undergoing major surgery were included prospectively. At 24 h, a logistic regressio...

A cohort, double blind, and randomized study was conducted to investigate the effect of a single nucleotide polymorphism of the μ-opioid receptor at nucleotide position 118 (OPRM1:c.118A>G) on the association with the most common side effects (nausea or vomiting) induced by intravenous patient control analgesia (IVPCA) with morphine, including incidence and severity analysis. A total of 129 Tai...

In EBioMedicine Meng et al. (2015a) reported the results from their second genome-wide association study on neuropathic pain that aimed to identify novel genetic factors contributing to neuropathic pain in diabetic patients. The first study (Meng et al., 2015b) published earlier this year in the European Journal of Pain identified a cluster in the Chr8p21.3, next toGFRA2 gene locus, associatedw...

10.2217/17410541.4.2.xxx © 2 Pr oo f Evaluation of: Munafò MR, Elliot KM, Murphy MFG, Walton RT, Johnstone EC: Association of the μ-opioid receptor gene with smoking cessation. Pharmacogenomics J. (2007). This well-designed study examined shortand long-term outcome data from a large clinical trial comparing nicotine-replacement therapy (NRT) with placebo in order to test the association between...

BACKGROUND This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. METHODS Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. RESULTS Among single nucleotide polymorphism markers in 13 candidate ge...

INTRODUCTION We recently reported that a majority of opioid-dependent Malay males on methadone therapy are cold pain sensitive. It is postulated that common OPRM1 polymorphisms may be responsible. This study investigated the association between 118A>G (dbSNP rs1799971) and IVS2+691G>C (dbSNP rs2075572) variants on cold pain responses among opioid-dependent Malay males on methadone maintenance t...