Coriandrum sativum (coriander) has been documented as a traditional treatment of diabetes. On the base of this belief and as the studies about whether coriander reduces hyperglycemia in diabetic mice is little known are lacking, we decided to evaluate the effect of Aqueous Extract seed of Coriander on optic nerve in Balb/c Diabetic Mouse. In the present study, the beta cells of pancreas of 16 b...

Congenital aplasia and hypoplasia of the optic nerves are rarely seen in human beings4 and an imak6 Similar conditions occur infrequently in but no detailed description of the condition has been given, except for the Bmn-wys strain of rat. Bmn-wys rats are animal models of inherited retinal degeneration; aplasia or hypoplasia of the optic nerve occurs in association with microphthalmosI0 in the...

Basic fibroblast growth factor (bFGF) is thought to be a trophic factor for several classes of neurons. Its distribution changes in response to cortical neural injury. We have determined the effect of injury to the optic nerve on localization of bFGF in the rodent retina and visual pathways. Our observations were confirmed by using different antisera and monoclonal antibodies. While photorecept...

BACKGROUND The observation of a buildup of mitochondria at the level of the lamina cribrosa in the optic nerve head has traditionally been attributed to axoplasmic stasis. However, this region is also the transition zone for myelination, resulting in differing energy requirements. OBJECTIVE To investigate the relationship between myelination and mitochondrial activity in optic nerve tissue. ...

BACKGROUND Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron and oligodendrocyte survival, axon regeneration, and (re)myelination. The therapeutic effects of ant...

To recognize and to assess glaucomatous changes at the optic nerve, it is important to know the characteristics of the normal optic disc. As in the other biological variables, the appearance of the optic disc varies widely among healthy individuals. This fact is complicate the recognition of the pathological changes. ‘Optic Disc’ is frequently used to describe the portion of the optic nerve cli...

PURPOSE To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway. MATERIALS AND METHODS A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the o...

Bilateral cavernous sinus and optic nerve metastases is extremely rare. We report an extremely rare case of metastatic adenocarcinoma of bilateral cavernous sinus and optic nerve with unknown primary presenting as orbital pseudotumor. She underwent bilateral optic nerve decompression and the diagnosis was established by biopsy.

PURPOSE To identify and characterize the MR findings of sarcoidosis when it involves the orbit and visual pathways. METHODS The MR scans of 15 patients, 3 with presumed and 12 with proved orbital or optic pathway sarcoidosis were retrospectively reviewed. RESULTS Eight patients had MR evidence of optic nerve involvement by sarcoid granuloma. Perineural enhancement was seen in four cases, op...