The significance of beam condition for scattered light from random tissue is analyzed for a practical optical imaging system with a finite numerical aperture. It is shown that in the transmitted illumination case, the information carrying part of the spectrum of the scattered light is proportional to the square of the spatial frequency of the spatial correlation function of the scattering poten...

High spatial and temporal resolutions are important advantages of optical imaging over other modalities. The recently developed spatial overlap modulation (SPOM) microscopy enables high resolution imaging by spatial modulation of double-beam overlap. However, SPOM suffers from bad temporal resolution and high system complexity. In this paper, we re-formulate the SPOM resolution theory and devel...

We describe a high-speed camera system for frequency domain imaging suitable for applications such as in vivo diffuse optical imaging and fluorescence lifetime imaging. 14-bit images are acquired at 2 gigapixels per second and analyzed with real-time pipeline processing using field programmable gate arrays (FPGAs). Performance of the camera system has been tested both for RF-modulated laser ima...

An ultracompact optical imaging system allowing various magnifications or demagnifications and based on microlenslet arrays is presented for the first time to our knowledge. This research generalizes recent findings regarding microlenslet-array-based 1:1 relay systems [Appl. Opt. 42, 6838 (2003)]. Through optical ray tracing, the feasibility of magnifying gray-scale images through a stack of tw...

Performing interventional procedures in the close proximity to an MR scanner widens the range of operations available for an optical tracking system. In order to gain the full benefits from both unrestricted use of surgical instruments outside the magnet and intraoperative imaging, a method for transferring the registration data of the optical navigator between two locations is required. An opt...

Stability is of utmost importance to a wide range of phase-sensitive processing techniques. In Doppler optical coherence tomography and optical coherence elastography, in addition to defocus and aberration correction techniques such as interferometric synthetic aperture microscopy and computational/digital adaptive optics, a precise understanding of the system and sample stability helps to guid...

We survey recently invented methods of optical tomographic imaging through scattering medium. The threedimensional structure of an object hidden between two biological tissues is recovered from many noisy speckle pictures obtained on the output of a multi-channeled optical imaging system.

We describe a novel dual-modality imaging approach that integrates diffuse optical tomography (DOT) and photoacoustic imaging (PAI) through a miniaturized handheld probe based on microelectromechanical systems (MEMS) scanning mirror. We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice system...

Based on a fluorescence imaging model, the optical filters, such as excitation and emission filters, are determined by linear discriminant analysis. The discriminability is a quadratic Rayleigh quotient of one filter if the other filter is assumed to be constant. The optical filters are optimized alternatingly and iteratively by solving their generalized eigenvalue problems. The proposed method...