OBJECTIVE Insulin causes capillary recruitment in muscle and adipose tissue, but the metabolic and microvascular effects of insulin in the skin have not been studied in detail. The aim of this study was to measure glucose metabolism and microvascular blood flow in the skin during local insulin delivery and after an oral glucose load. METHODS Microdialysis catheters were inserted intracutanous...

BACKGROUND There is relevant between individual variability in paracetamol clearance in young women. In this pooled study, we focused on the population pharmacokinetic profile of intravenous paracetamol metabolism and its covariates in young women. METHODS Population PK parameters using non-linear mixed effect modelling were estimated in a pooled dataset of plasma and urine PK studies in 69 y...

Oral drug delivery system has been area of interest for researcher and scientist to explore it to the extreme potential in drug delivery system in past few years. The researchers are focusing on this drug delivery because of ease of administration and comfort offered by this route to patient. Hence drug delivery can be achieved by incorporating medicament in Chewing gum (CG) base because oral m...

The purpose of this paper was to highlight 6 important considerations for developing a comprehensive strategy for optimizing the oral health of preschoolers. These considerations are based on the nature of Early Childhood Caries and the strengths and limitations of various components of the pediatric health care delivery system. Emphasized are 3 strategies for optimizing oral health care delive...

Peroral protein/peptide delivery has been one of the most challenging, but encouraging topics in pharmaceutics. This article was intended to explore the potential of biotin-modified liposomes (BLPs) as oral insulin delivery carriers. By incorporating biotin-DSPE into the lipid bilayer, we prepared BLPs using reverse evaporation/sonication method. We investigated hypoglycemic effects in normal r...

Receptor-mediated endocytosis can be exploited for improving the transcellular delivery of therapeutic proteins. Insulin conjugated to transferrin by forming disulfide bonds has been shown to improve insulin oral bioavailability in diabetic rats. We are developing a combination strategy involving complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. The complexation hy...

OBJECTIVES This investigation examined human papillomavirus (HPV) in pregnant women in order to characterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity. METHODS A total of 577 pregnant women seeking routine obstetric care were evaluated for HPV infection in their cervix during gestation and immediately before delivery, and in the oral cavity...

Oral drug delivery route is the most preferable route of drug delivery. It is due to various advantages of this route like ease of administration, patient compliance and flexibility in the formulations. Oral dosage form has really progressed from immediate release to site-specific delivery. The recent scientific and patented literature concluded that an increased interest in novel dosage forms ...

BACKGROUND To compare oral and transdermal delivery systems in domains of lipid effects; cardiovascular, inflammatory, and thrombotic effects; effect on insulin-like growth factor, insulin resistance, and metabolic syndrome; sexual effects; metabolic effects including weight; and effects on target organs bone, breast, and uterus. METHODS Review of the literature 1990-2010. Studies selected on...