BACKGROUND Each year, more than forty million abortions are occurred whole of the world. Misoprostol is a prostaglandin analogue with a strong uterotonic effect. The present study aimed to compare the efficacy of Misoprostol in first trimester abortion through two sublingual and vaginal routes of administration. METHODS This randomized clinical trial was conducted on 52 consecutive women in f...

Objective: Optimal pain management during medical termination of pregnancy (TOP) remains unclear. This study aimed to suggest practical points help minimize the intensity women first trimester TOP. Methods: A retrospective observational which reviewed experience and need for analgesics 44 Asian women, who underwent Results: Nulliparous had higher scores more likely than multiparous women. Most ...

Misoprostol is a synthetic analogue of prostaglandin E1 that is administered to women at high doses to induce uterine contractions for early pregnancy termination and at low doses to aid in cervical priming during labor. Because of the known teratogenic effects of misoprostol when given during gestation and its effects on axonal growth in vitro, we examined misoprostol for its potential as a ne...

OBJECTIVE To report a case of a child born with Möbius syndrome following exposure in utero to mifepristone and misoprostol for elective abortion. CASE SUMMARY In the seventh week of pregnancy, a woman was administered mifepristone 600 mg and, 2 days later, misoprostol 400 mug for abortion. One month later, despite significant metrorrhagia, an ultrasound examination showed ongoing gestation. ...

Background: Abortion is the medical or surgical termination of pregnancy before 20th week. However, dilation and curettage have been associated with hazards such as uterine rupture, heavy bleeding, infection. Therefore, in recent decades, pharmacological therapies become more widely accepted. Objectives: This research compared abortion success rates misoprostol/letrozole versus misoprostol/plac...

BACKGROUND The pharmacokinetics of a novel slow-release (SR) misoprostol was studied and compared to conventional misoprostol. METHODS Thirty-one women, pregnant between 8 and 12 weeks, requesting surgical abortion were randomly allocated to receive orally 400 microg conventional misoprostol, 400 microg SR misoprostol or 800 microg SR misoprostol. Venous blood samples were taken at 0, 30, 60,...

BACKGROUND The dose of mifepristone approved by most government agencies for medical abortion is 600 mg. Our aim was to summarize extant data on the effectiveness and safety of regimens using the widely recommended lower mifepristone dose, 200 mg, followed by misoprostol in early pregnancy and to explore potential correlates of abortion failure. STUDY DESIGN To identify eligible reports, we s...

Early termination of pregnancy (ETP) is a common procedure, with surgical intervention being the prevailing method. However, it carries inherent risks. This case report describes 27-year-old woman history left hip surgery who sought termination. Due to her limited abduction, positioning for posed challenges. The patient underwent dilatation and curettage after cervical preparation misoprostol v...

Nigeria has restrictive abortion laws; unsafe abortion and its complications are major public health challenges. Access to reproductive health services in Nigeria, including medical abortion, is poor. We determined the socio-demographic characteristics, patterns of abortion practices, and experiences of medical abortions among abortion seekers in southeastern Nigeria. We carried out a descripti...