metastatic tumors account for 1% of all oral malignancies. metastasis to jaw bones is common, particularly in the mandible, rare in the oral soft tissues, and account for only 0.1% of oral malignancies. the majority of metastatic cases (70%) reported in the literature have primary tumors located in the lung, breast, kidney, and colon. metastasis is a biological complex process that involves det...

background: the effectiveness of low power lasers on incisional wound healing, because of confl icting results of previous studies, is uncertain. therefore, the aim of this study was to evaluate the effects of low-level helium-neon (he-ne) laser irradiation on wound healing in rat’s oral mucosa. materials and methods: sixty-four standardized incisions were carried out on the buccal mucosa of 32...

BACKGROUND In dental implant treatment, the long-term prognosis is dependent on the biologic seal formed by the soft tissue around the implant. The in vitro investigation of the implant-soft tissue interface is usually carried out using a monolayer cell-culture model that lacks a polarized-cell phenotype. This study developed a tissue-engineered three-dimensional oral mucosal model (3D OMM) to ...

Background: Recent researches have provided evidences of the importance of endothelin axis in carcinogenesis. According to our knowledge, no data exists about endothelin A receptor (ETA) expression in dysplastic oral mucosa (DOM). Therefore, the aim of the present study was to evaluate immunohistochemical expression of ETA in DOM. Methods:</strong...

Aberrant glycosylation during carcinogenesis results in altered glycan expression on oral cancer cells. The objective of this study was to detect this atypical glycosylation via imaging of fluorophore-conjugated lectins. Paired normal and tumor tissue from seven patients with oral squamous cell carcinoma were investigated for sialic acid expression via the legume protein wheat germ agglutinin (...

Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy include but are not limited to an increased susceptibility to dental caries and periodontal disease. They also include profound and often permanent functional and sensory changes involving the oral soft tissue...

Tissue engineering of bone and oral mucosa have been extensively studied independently. The aim of this study was to develop and investigate a novel combination of bone and oral mucosa in a single 3D in vitro composite tissue mimicking the natural structure of alveolar bone with an overlying oral mucosa. Rat osteosarcoma (ROS) cells were seeded into a hydroxyapatite/tri-calcium phosphate scaffo...

metastases of internal tumors to the oral cavity are unusual and in most cases involve maxilla and mandible. metastases to the gingival soft tissue are extremely rare. reporting a new clinical case of renal cell carcinoma (rcc) metastasis with an unusual site. metastatic involvement of gingival tissue with renal cell carcinoma is an extremely rare clinical event. it is usually associated with i...

background and aims. the onset of opportunistic infections in hiv-positive patients is generally associated with a low cd4 count. oral manifestations can be the first clinical sign of the infection and also determine the progression of disease. the purpose of this study was to determine the prevalence of oral soft tissue manifestations and their relationship with the degree of immunosuppression...

aim : the study aims to document the oral lesions in patients with uc. background : inflammatory bowel disease (ibd) is comprised of two chronic, tissue-destructive and clinical entities including crohn's disease (cd) and ulcerative colitis (uc), both of which are immunologically based. patients and methods : the population of the study includes fifty patients with uc, as the experimental group...