In recent years the science of tissue engineering has emerged as a powerful tool for the development of a novel set of tissue replacement parts and technologies. Recent advances in the fields of biomaterials, stem cell technologies, growth factor field and biomimetics have created a unique set of opportunities for investigators to fabricate lab-grown tissues from combination of extracellular ma...

BACKGROUND To investigate the prevalence of cumulative organ damage among Egyptian children with juvenile-onset systemic lupus erythematosus (jSLE) and the relationships between the organ damage and the demographic data, clinical variables, and disease activity. METHODS A total of 148 patients with jSLE have been followed in the pediatric rheumatology clinic and section at Cairo University. T...

background: a reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ-isms to kill the parasite. however, it is not well known whether these intermediates cause dna damage and oxidative stress in goats infected with babesia ovis . the pur-pose of this study was to clarify the effects of babesiosis on basal leve...

in order to examine the effect of the quantity of nitrogen fertilizer and bush density on vegetative and productive function of henna medicinal plant (lawsonia inermis)  factorial experimentation in the form of block plan was carried in three stages in agriculture research center in south of kerman  province in corp of 2012. the first factor containing nitrogen fertilizer in 4 levels including ...

INTRODUCTION Sickle cell disease is highly prevalent in Africa with a significant public health burden. Nonetheless, morbidity and mortality in sickle cell disease that result from the progression of organ damage is not well understood. The Organ Damage in Sickle Cell Disease Study (ORDISS) is designed as a longitudinal cohort study to provide critical insight into cellular and molecular pathog...

Arterial hypertension and chronic kidney disease are mutually interconnected. Uncontrolled arterial along with diabetes is one of the two most common causes end-stage disease. On other hand, disease, as well renal artery stenosis, results in development hypertension. Hypertensive crisis target-organ damage, also known a hypertensive emergency, serious complication which however becoming less fr...

Sterile inflammatory insults, such as ischemia-reperfusion (I/R) injury, result from pathogenic factors, including damage-associated molecular pattern signaling, activation of innate immunity, and upregulation of proinflammatory cytokines. At the same time, a number of protective, or prosurvival, pathways are also activated, and the extent of end-organ damage is ultimately determined by the bal...

Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of ...

Severe forms of hypertension are characterized by high blood pressure combined with end organ damage. Through the development and refinement of a transgenic rat model of malignant hypertension incorporating the mouse renin gene, we previously identified a quantitative trait locus on chromosome 10, which affects malignant hypertension severity and morbidity. We next generated an inducible malign...

hydrocarbons are ubiquitous in daily life and include plant and animal fats, alcohols, solvents, natural gas, petroleum derivates. majority of intoxication reports of hydrocarbons are due to inhalation or ingestion, but there is few reports about intravenous injection of gasoline. we report a 58 year-old man who injected gasoline intravenously for suicide. he developed soft tissue necrosis of f...