Abstract Sunflower trypsin inhibitor‐1 (SFTI‐1) structure is used for designing‐grafted peptides as a possible therapeutic agent. The grafted peptide exhibits multiple conformations in solution due to the presence of proline peptide. To lock into major conformation solution, dibenzofuran moiety (DBF) was incorporated backbone structure, replacing Pro‐Pro sequence. NMR studies indicated solution...

Kentucky bluegrass (Poa pratensis L.) is one of the most widely used turfgrasses for home lawns, golf courses, parks, and athletic fields in temperate climates. Oxidative stress caused by drought stress is a major limiting factor for grass cultivation in arid and semi-arid regions. The objective of this study was to investigate whether Prohexadione-Calcium (Pro-Ca) may play a role in promoting ...

Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been attributed to their selective permeation of small cations (e.g., Ca2+, Na+ and K+), and the ion selectivity has been assumed to be an invariant fingerprint to a given channel. However, for TRPV1, the notion of in...

The lymphocyte toxicity assay (LTA) is a proposed surrogate marker of sulfonamide antibiotic hypersensitivity. In the LTA, peripheral blood mononuclear cells (PBMCs) undergo apoptosis more readily in hypersensitive versus tolerant patients when exposed to drug-hydroxylamine metabolites in vitro. The purpose of this study was to identify key gene transcripts associated with increased cytotoxicit...

The aim of the current study was to establish the epidermal growth factor receptor (EGFR) ligand expression profile in human airway epithelial cells exposed to either particulate matter (PM) with an aerodynamic diameter <2.5 microm (PM(2.5)) or its components and the involvement of EGFR ligands in PM(2.5)-provoked airway inflammation. EGFR ligand mRNA and protein expression were studied in a hu...

We employ the achiral liquid chromatography with diode array, evaporative light scattering and mass spectrometric detection (HPLC-DAD, HPLC-ELSD and LC-MS) to assess structural instability (understood as spontaneous oscillatory chiral conversion and spontaneous oscillatory condensation) of the two pairs of amino acids, L-proline-L-phenylalanine (L-Pro-L-Phe) and L-hydroxyproline-L-phenylalanine...

Background. The etiology of neurodegenerative disorders, such as the accelerated loss of dopaminergic neurons in Parkinson’s disease, is unclear. Current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter DAT to contribute to cell death in the dopaminergic system, but it has not been investigated whether sodium-independent amine transporters are implic...

background: endometriosis is a female health disorder that occurs when cells from the lining of the uterus grow in other areas of the body. the cause of endometriosis is unknown. objective: the purpose of this study was to investigate tp53 gene codon 72 polymorphism in women with endometriosis and compared it with healthy samples in isfahan. materials and methods: we undertook a case-control st...