I would like to compliment ‘Indian Pediatrics’ for publishing and providing a solution to the recurrent annual outbreaks of a mysterious fatal disease affecting young children of western UP and Uttarakhand for last many years(1). This illness often labeled as ‘acute viral encephalitis’by the investigating agencies and ‘brain fever’ by lay media has been puzzling pediatricians and public health ...

background: it is becoming apparent that although inhibition of cholinesterase plays a key role in organophosphate (op) toxicity, other factors are also important. one of the contributing factors for severity of op poisoning is electrolyte imbalances such as hypokalemia. this study was aimed at evaluating the value of hypokalemia in association with plasma cholinesterase (pche) levels in predic...

Bacterial enzymes have been isolated that catalyze the hydrolysis of organophosphate nerve agents with high-rate enhancements and broad substrate specificity. Mutant forms of these enzymes have been constructed through rational redesign of the active-site binding pockets and random mutagenesis to create protein variants that are optimized for the detoxification of agricultural insecticides and ...

Accidental organophosphate poisoning may occur in persons coming in close contact with animals being treated toitb organophosphate pesticides. The poisoning may manifest itself as a severe systemic disorder, but can be diagnosed by an alert physician and confirmed by specific tests of reduced cholinesterase activity in the blood, plasma and red blood cells. Treatment is with intravenous atropin...

Organophosphate (OP) poisoning is one of the most common toxicological emergencies, especially in developing countries. They work by inhibiting cholinesterase enzyme lead to severe cholinergic toxicities. Organophosphorus intoxication occurs after cutaneous exposure, respiratory inhalation or gastrointestinal tract absorption. Exposure to organophosphate and other agents increases yearly, with ...

Insecticide-resistant populations of TPB have been noted in the Delta region (Hollingsworth et al., 1 ; Snodgrass, 1 ). Proposed EPA regulatory constraints on organophosphate insecticide use are anticipated. Viable replacements for organophosphate insecticides are needed. These may include efficient, long-lasting, and specific biological control agents. In this study, a commercially available B...