At the experimental heavy ion therapy facility at the GSI Darmstadt an in-beam PET scanner is operated for quality assurance monitoring simultaneously to the therapeutic irradiation. A fully 3D maximum likelihood expectation maximization (MLEM) reconstruction algorithm has been developed and adapted to the special conditions of in-beam PET [1]. The system response function (system matrix) for t...

Background: The quality of positron emission tomography/computed tomography (PET/CT) images plays an important role in tumor detection. This imaging method often yields poor-quality overweight patients due to the high level noise, originating from scattering and photon attenuation. Objectives: point spread function (PSF) is mostly used enhance spatial resolution signal-to-noise ratio (SNR); how...

BACKGROUND In targeted radionuclide therapy (TRT), accurate quantification using SPECT/CT images is important for optimizing radiation dose delivered to both the tumour and healthy tissue. Quantitative SPECT images are regularly reconstructed using the ordered subset expectation maximization (OSEM) algorithm with various compensation methods such as attenuation (A), scatter (S) and detector and...

BACKGROUND Accurate staging is crucial for treatment selection and prognosis prediction in patients with rectal cancer. Point spread function (PSF) reconstruction can improve spatial resolution and signal-to-noise ratio of PET imaging. The aim of this study was to evaluate the effectiveness of 18F-FDG PET/CT with PSF reconstruction for initial staging in rectal cancer compared with conventional...

Received 12/27/2000; revised 2/26/2001; accepted 3/14/2001. For correspondence or reprints contact: Habib Zaidi, Ph.D., Division of Nuclear Medicine, Geneva University Hospital, CH-1211 Geneva, Switzerland. Tel: 41 22 372 72 58, Fax: 41 22 372 71 69, E-mail: [email protected] A new method to assess the scatter component in positron emission tomography (PET) based on estimating the low-freque...

OBJECTIVE Prone positioning, iterative reconstruction (IR-OSEM) and electrocardiography (ECG) gating have been demonstrated to improve the specificity of myocardial perfusion SPECT (MPS) in the diagnosis of coronary artery disease. METHODS The gated supine and prone MPS images of 45 patients were reconstructed with both IR-OSEM [supine (SIR) and prone (PIR)] FBPs [supine (SFBP), prone (PFBP)]...

BACKGROUND Our aim was to evaluate if a recently introduced TOF PET system with digital photon counting technology (Philips Healthcare), potentially providing an improved image quality over analogue systems, can fulfil EANM research Ltd (EARL) accreditation specifications for tumour imaging with FDG-PET/CT. FINDINGS We have performed a phantom study on a digital TOF PET system using a NEMA NU...

Introduction: Gated SPECT myocardial perfusion scanning has new capabilities in addition to its main applications such as left ventricular dyssynchrony using phase analysis. Phase analysis has been investigated through various software including Emory Cardiac Toolbox (ECTb) and Quantitative Gated SPECT (QGS). The aim of this study is to evaluate the effect of reconstruction par...

Abstract Prostate cancer is one of the most common cancers affecting men. Bone scan part staging modality commonly used to evaluate bone metastasis. A with diffused increased skeletal tracer uptake relative soft tissue, combined faint renal activity known as a superscan. However, primary concern are false negatives associated scans, where diffuse metastasis indistinguishable on superscans. In t...