INTRODUCTION: Infection is a devastating orthopaedic complication when associated with fractures stabilized with internal fixation. Infection impairs fracture healing. In addition, bacteria adhere to the surfaces of a metallic fixation device and synthesize a glycocalyx, insulating them from host and antibiotic assault. Effective treatment of the infection often requires removal of the fixation...

Hydroxyapatite (HAp) ceramics based on calcium phosphates, chemical compounds being natural constructive element of bones is now regarded to be one of better implantation materials in osseous surgery and stomatology. HAp is poorly soluble and slowly resorbing in tissues material. Easiness of connecting of hydroxyapatite ceramics with other materials creates possibilities to produce new composit...

Development of tools to be used for in vivo bone tissue regeneration focuses on cellular models and differentiation processes. In searching for all the optimal sources, adipose tissue-derived mesenchymal stem cells (hADSCs or preadipocytes) are able to differentiate into osteoblasts with analogous characteristics to bone marrow mesenchymal stem cells, producing alkaline phosphatase (ALP), colla...

Samples of porous Ti metal were subjected to different acid and heat treatments. Ectopic bone formation on specimens embedded in dog muscle was compared with the surface characteristics of the specimen. Treatment of the specimens by H2SO4/HCl and heating at 600 °C produced micrometer-scale roughness with surface layers composed of rutile phase of titanium dioxide. The acid- and heat-treated spe...

BACKGROUND The purpose of the study is to investigate whether autologous platelet-rich plasma (PRP) can serve as bone-inducing factors to provide osteoinduction and improve bone regeneration for tissue-engineered bones fabricated with bone marrow mesenchymal stem cells (MSCs) and beta-tricalcium phosphate (β-TCP) ceramics. The current study will give more insight into the contradictory osteogen...

The review is based on the analysis of 53 literature sources from PubMed, Google, Google Scholar, and Cochrane Library. Among substitutes for autogenous bone grafts in spine surgery, ceramic biomaterials are largest studied group, among which certain niche occupied by calcium phosphate ceramics (CPCs). Hydroxylapatite, tricalcium biphasic with all parts hydroxylapatite widely used surgery. adva...

In vitro electrochemical characterization and in vivo implantation an animal model were employed to evaluate the degradation behaviour biological activity of FeMnSi FeMnSiCa alloys obtained using UltraCast (Ar atmosphere) melting. Electrochemical was based on open circuit potential measurement, impedance spectroscopy potentiodynamic polarization techniques while immersed Ringer's solution at 37...

Bone repair using BMP-2 is a promising therapeutic approach in clinical practices, however, high dosages required to be effective pose issues of cost and safety. The present study explores the potential low dose treatment via tissue engineering approach, which amalgamates 3-D macro/microporous-nanofibrous bacterial cellulose (mNBC) scaffolds primed murine mesenchymal stem cells (C3H10T1/2 cells...