OBJECTIVES Since 2004, the government of Tanzania has been rolling out antiretroviral treatment programs all over the country. However, the capacity of the health system to cope with the rapid scale-up of these programs is a major concern, and problems may result in drug stock-outs that force changes in treatment regimens. This study aims to explore stock-outs of antiretroviral drugs and furthe...

Results confirming the vaccine’s strong protection against COVID-19 were welcomed following last week’s pause in roll-outs — but fresh questions have now emerged about data.

Gastrulation is a critical stage of metazoan development during which endodermal and mesodermal tissues are internalized, and morphogenesis transforms the early embryo into each animal's unique body-plan. While gastrulation has been studied extensively in classic model systems such as flies, worms, and vertebrates, less is known about gastrulation at a mechanistic level in other taxa. Surprisin...

Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic acid capsule and the tripartite anthrax toxin. The discovery of the anthrax toxin receptors in the early 2000s has allowed in-depth studies on the...

IN THEIR REPORT “SOIL FERTILITY AND BIOdiversity in organic farming,” P. Mäder et al. (31 May, p. 1694) downplay two factors in their discussion of the relative merits of organic and conventional farming. First, because organic farming yields (per unit of land) were 20% lower than those from conventional farming, 25% more land would be required to produce the same amount of crop biomass, offset...

Cellular self-eating promotes pancreatitis T o survive tough times, cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. In autophagy, a vesicle swallows a portion of cytoplasm and ferries it to the lysosome for digestion. The process is often b...

w e all use spectral-domain optical coherence tomography (SD-OCT) as a critical tool in preoperative planning for our most routine surgical cases like macular holes, epiretinal membranes, and vitreomacular traction. After our case is completed, we can see the result with SD-OCT: a closed macular hole, removed epiretinal membrane (ERM), and release of macular traction with foveal relaxation. But...

The anatomy of the entorhinal-hippocampal circuit suggests how spatial information may flow into and out of the CA1 region. In this issue of Neuron, two groups use in vivo physiology to make predictions about the circuit mechanisms involved in the encoding and maintenance of spatial memory. Brun et al. show that lesions of the cells providing direct input from the mEC to CA1 lead to a decrease ...