This review examines the evidence for a central role of oestrogen receptor b (ERb or ESR2 as listed in the MGI Database) in folliculogenesis and hence reproductive biology. Knockout mouse models have been a valuable resource in this respect. The ERb-null mouse exhibits a granulosa cell phenotype associated with the partial arrest of folliculogenesis and ovulatory dysfunction. Phyto-oestrogens s...

Biological assays were used to evaluate the effect of the insect growth regulator fenoxycarb (ethyl (2-p-phenoxyphenoxy) ethyl carbamate) on production of queen-derived dealation inhibitory pheromone and the queen recognition pheromone of Solenopsis invicta Buren. Treated virgin and mated queens weighed less and were less capable of inhibiting dealation by female alates than were nontreated con...

background: premature ovarian failure (pof) is a disorder of multi causal etiology. autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in pof. the aim of this study was to identify the level of auto-antibodies in pof and familial pof patients. materials and methods: in this study, auto-antibodies including anti-ovarian antibody (aoa), a...

Background: Chemotherapy agents can cause ovarian dysfunction and eventually lead to infertility. This study investigated the effect of nasturtium officinale extract on the ovarian function following the toxicity induced by doxorubicin in female rats. Methods: Forty eight female Wistar rats (180-210g) were randomly divided in six groups as follows: Group I, normal rats receiving 1ml normal sal...

BACKGROUND Polycystic ovary syndrome (PCOS) patients typically have 17-hydroxyprogesterone (17OHP) hyperresponsiveness to GnRH agonist (GnRHa) (PCOS-T). The objective of this study was to determine the source of androgen excess in the one-third of PCOS patients who atypically lack this type of ovarian dysfunction (PCOS-A). METHODS Aged-matched PCOS-T (n= 40), PCOS-A (n= 20) and controls (n= 3...

Background: Infertility therefore affects approximately 10-15% of couples and is an important part of practice of many clinicians .the most important factor of infertility include: male factor(40%) female factor ( 40%) , both of them (10%) and unexplained infertility (10%).The purpose of this study is evaluation of the cause of infertility in patients who are referred to Razavi hospital inferti...

failure to respond adequately to standard protocols and to recruit adequate follicles is called ‘poor response’. this results in decreased oocyte production, cycle cancellation and, overall, is associated with a significantly diminished probability of pregnancy. it has been shown that ovarian reserve tests, such as basal fsh, antimullarian hormone (amh), inhibin b, basal estradiol, antral folli...

background: ovarian fibroma is the most common benign solid tumor of the ovary, which is often difficult to diagnose preoperatively. the choice treatment for ovarian fibroma is surgical removal, but discussions for the operative approach, laparoscopic or open, in the literature seem to be scant. case presentation: we presented a unique clinical experience of laparoscopic approach to a case of 1...

STUDY QUESTION Do any mutations in growth differentiation factor 9 (GDF9) have a role in diminished ovarian reserve (DOR) in young women? SUMMARY ANSWER The GDF9 p.R146C mutation may be a source of DOR in some young women. WHAT IS KNOWN ALREADY DOR affects 10% of women under 37 years of age and is associated with accelerated expenditure of follicles. GDF9 is an oocyte-secreted factor that p...