Evidence exists to support the concept of sex difference in immune system activation by pyrogenic cytokines. In this study, fever development was monitored to analyze the effect of peripheral administration of interleukin (IL)-1beta (1 microgram/kg) in adult male and cycling or ovariectomized female rats with or without ovarian hormonal replacement. In male and randomly cycling female rats, a s...

the majority of cancer treatments are invasive. gonadal injuries cause reductions in fertility which results in lack of hope for conception in cancer patients and frustration for their partners. fortunately, current advancements in cryopreservation and transplantation sciences regarding fertility preservation lead to cryostorage of gonads and preservation prior to the onset of chemo- and radiot...

Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are integrated throughout the life cycle of the follicle to ensure appropriate hormone secretion, differentiation of the somatic cells, and maturation of the oocyte. The process of in-f...

In addition to providing highly effective contraception, combined oral contraceptives (COCs) afford a broad range of additional non-contraceptive benefits including regulation of menstruation with reduced bleeding and pain, improved complexion, reduction in benign breast disease, reduced ovarian cyst formation, and a 50% decrease in rates of ovarian and uterine cancer. The low doses of hormones...

The release of gonadotropins is the main endocrine signal regulating ovulation and the release of hormones by the ovaries. Several types of growth factors modulate the effects of gonadotropins on the follicular, luteal and interstitial compartments of the ovaries. During the last 30 years, numerous studies have indicated that the ovarian innervations play a role in modulating the effects that g...

Ovarian cancer is the seventh most common cancer in women and the most lethal gynecological cancer, causing over 151,000 deaths worldwide each year. Dysregulated production of endocrine hormones, known to have pluripotent effects on cell function through the activation of receptor signaling pathways, is believed to be a high-risk factor for ovarian cancer. An increasing body of evidence suggest...

Steroid hormones have been implicated in the etiology and/or progression of epithelial ovarian cancer. As ovarian surface epithelial cells are growth inhibited by transforming growth factor beta (TGF-beta), we tested whether steroid hormones could regulate the expression of TGF-beta1 or its receptors in ovarian cancer cells, as assessed by quantitative reverse transcription-PCR. Treatment of ov...

Fertility results from coordinate functioning of components of the hypothalamic-pituitary-ovarian-genital axis. In normal women, ovarian sex steroid hormones act as the mediators of these interactions.Infertility is a clinical manifestation of the failure of one or more of the components to function appropriately. Determining the locus of dysfunction provides the basis for rational treatment. F...

Ovarian follicular development is dependent on the actions and interactions of the pituitary gonadotropins, FSH and LH, and the ovarian steroid hormone, estradiol. Agents which might block the effects of these hormones would increase follicular atresia and reduce fertility. In addition, any substance toxic to the oocyte and its normal pattern of growth and meiosis would lead to reduced numbers ...