introduction: the purpose of this study was to determine alkaline phosphatase (alp) activity of ovary after ovarian induction using pregnant mare serum gonadotropin (pmsg) and human chorionic gonadotropin (hcg) during implantation periods. material and methods: a total of 240 female nmri mice aged 6-10 weeks were selected and divided into control and hyperstimulated. these mice were rendered no...

We show here that elevated levels of gonadotropins (luteinizing hormone and follicle stimulating hormone), as found in menopause or after ovariectomy, promote growth of human ovarian carcinoma by induction of tumor angiogenesis. Human epithelial ovarian cancer tumors progressed faster in ovariectomized mice. This induced growth could be attributed to the elevated levels of gonadotropins associa...

the cyclical changes in the gonadotropins stimulate ovarian follicular development either to the ovulatory stage or to undergo atresia. one such intrafollicular factor may be inter-cellular communication via gap junctions. we have examined the effects of two agents (retinoids and alkanols), known to disrupt or uncouple gap junction, on fsh-stimulated lh receptor induction and progestrone synthe...

1) Induction of ovarian tumor with a single intragastric instillation of a large but tolerable doses of 7,12-dimethylbenz[a]anthracene (DMBA) was investigated on young female mice of C3H and C57BL strains, rats of Sprague-Dawley strain, guinea pigs, and rabbits. The ovarian tumor occurred in a high incidence only in C3H mice. 2) The induction of ovarian tumor in C3H mice with DMBA by various ro...

In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patients. In the tumor and malignant ascites, CD4(+)CD123(+)BDCA2(+) pDC were the m...

The expression level of interleukin-8 (IL-8) directly correlates with the progression of human ovarian carcinomas implanted into the peritoneal cavity of nude mice, but the mechanism of induction is unknown. Because hypoxia induces expression of vascular endothelial growth factor/vascular permeability factor, which, like IL-8, is an angiogenesis-regulating molecule, we determined whether hypoxi...

BACKGROUND Ovarian carcinoma is the leading cause of death from gynecological cancer because there is risk of chemoresistance. As previously demonstrated in our laboratory, Alpha-lipoic acid (LA), a co-factor for metabolic enzymes, suppresses the tumor growth. In this study, we have researched the mechanisms that are responsible for the activity of LA. METHODS We have studied the mechanisms o...

In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patients. In the tumor and malignant ascites, CD4þCD123þBDCA2þ pDC were the most ab...