Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...

The ability to observe chemical reactions at the molecular level convincingly demonstrates the physical and chemical phenomena occurring throughout a reaction mechanism. Videos obtained through in situ transmission electron microscopy (TEM) revealed the oxidation of catalytic soot under practical reaction conditions. Carbon oxidation reactions using Ag/SiO2 or Cs2CO3/nepheline catalysts were pe...

The vanadium-based catalyst, acts as a homogeneous catalyst for the selective oxidation of various kinds of sulfides with 30% aqueous H2O2. Vanadium-based catalyst was successfully used as the oxygen source for the oxidation of sulfides to sulfoxides for the first time. The sulfoxides were obtained in a good way to high yields without any detectable over-oxidation to sulfones under normal condi...

we studied the effect of different concentrations of alpha-tocopherol on in vitro cupric ions induced oxidation of low density lipoproteins (ldl). human native ldl (50 µg protein/ml) oxidation was induced by 10 µmol/l of cuso4. conjugated dienes were measured spectrophotometrically for up to 440 minutes. the length of the lag phase (tlag), maximum velocity of the reaction (vmax) and the maximum...

core-shell nanostructures are emerging as more important materials than alloy nanostructures and have much more interesting potential applications in various fields. in this work, we demonstrated the fast and facile synthesis of core-shell nanoparticles consisting of pt thin layer as the shell and ni nanoparticles as the cores. the described method herein is suitable for large-scale and low-cos...

a mild, efficient and fast method for the oxidation of alcohols and trimethylsilyl, tetrahydropyranyl and methoxymethyl ethers to their corresponding carbonyl compounds using cro3 in the presence of rice husk ash (rha) is reported. all reactions were performed at room temperature in high to excellent yields. a new, efficient and green catalyst, heterogeneous reaction conditions, easy work-up of...

Motor oil serves as a useful model system for atmospheric oxidation of hydrocarbon mixtures typical of anthropogenic atmospheric particulate matter, but its complexity often prevents comprehensive chemical speciation. In this work we fully characterize this formerly "unresolved complex mixture" at the molecular level using recently developed soft ionization gas chromatography techniques. Nuclea...

Ferric leghemoglobin reductase (FLbR) from soybean (Glycine max [L.] Merr) nodules catalyzed oxidation of NADH, reduction of ferric leghemoglobin (Lb(+3)), and reduction of dichloroindophenol (diaphorase activity). None of these reactions was detectable when O(2) was removed from the reaction system, but all were restored upon readdition of O(2). In the absence of exogenous electron carriers an...

BACKGROUND Oxygen-base (O-base) oxidation in protein backbone is important in the protein backbone fragmentation due to the attack from reactive oxygen species (ROS). In this study, an alanine peptide was used model system to investigate this O-base oxidation by employing density functional theory (DFT) calculations combining with continuum solvent model. Detailed reaction steps were analyzed a...

Oxidation of the heme-thiolate enzyme chloroperoxidase (CPO) from Caldariomyces fumago with peroxynitrite (PN) gave the Compound II intermediate, which was photo-oxidized with 365 nm light to give a reactive oxidizing species. Cryo-solvents at pH ≈ 6 were employed, and reactions were conducted at temperatures as low as -50° C. The activity of CPO as evaluated by the chlorodimedone assay was una...