نتایج جستجو برای: oxidative phosphorylation respiration
تعداد نتایج: 257783 فیلتر نتایج به سال:
The low rate of endogenous respiration exhibited by the blue-green algae Anacystis nidulans and Phormidium luridum was not increased by the addition of respiratory substrates. However, endogenous respiration was inhibited by low concentrations of cyanide and by high carbon monoxide tensions. In addition, the uncouplers dinitrophenol and carbonyl cyanide p-trifluoromethoxyphenylhydrazone both st...
The inhibition of glycolysis by respiration (Pasteur effect) and the inhibition of respiration by glycolysis (Crabtree effect) represent nonhormonal regulatory mechanisms of cellular metabolism. Some of the previous work on these phenomena in intact cells will be reviewed in subsequent papers (1, 2) together with a report on recent experimental work on ascites tumor cells. The difficulty of obt...
Hepatocellular carcinoma (HCC) is the third major cause of cancer-related death worldwide and responds positively to tyrosine kinase inhibitors (TKIs). Dasatinib (Das) an Src/Abl family has been successfully utilized in treatment various cancers. Cancer cells are known limit their oxidative phosphorylation minimize stress. Palmitoylcarnitine (Pcar) incubation triggers mitochondria-mediated apop...
FOR HALF A CENTURY, comparative physiology has been profoundly influenced by the Nobel laureate August Krogh’s dictum (4) that “for a large number of problems, there will be some animal of choice with which it can be most conveniently studied.” As one who did research on insect respiration, Krogh would have greatly admired the work of Chamberlin (1) appearing in this issue of the American Journ...
Purpose To characterize retinal mitochondrial respiration associated with type 2 diabetes (T2D) progression in a cone-rich diurnal rodent, the Nile rat (genus Arvicanthis, species niloticus). Methods Nile rats were fed a standard rodent diet that resulted in rising glucose levels from 6 months. Age-matched control animals were fed a high-fiber diet that prevented diabetes up to 18 months. The...
Sepsis is characterized by a generalized inflammatory response and organ failure, associated with mitochondrial dysfunction. Hydrogen sulfide donor NaHS has anti-inflammatory properties, is able to reduce metabolism and can preserve mitochondrial morphology and function. Rats were challenged with live Streptococcus pneumonia or saline and infused with NaHS (36 µmol/kg/h) or vehicle. Lung and ki...
The effects of the local anesthetic bupivacaine on the oxidative phosphorylation in rat liver mitochondria were examined. Bupivacaine caused a maximum of about 7-fold stimulation of state 4 respiration at about 3 mM, released oligomycin-inhibited state 3 respiration, and activated ATPase to a similar extent to that by the weakly acidic uncoupler SF 6847. These effects were greatly enhanced by t...
The influence of K+ on oxidative phosphorylation of rat liver mitochondria has been investigated. Fresh mitochondria undergo a loss of respiratory control concomitantly with the loss of K+, and a rough correlation was found between the K+ content of the mitochondria and the State 3 to State 4 respiratory ratio. K+-depleted mitochondria have a low respiratory control with NAD-dependent substrate...
EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown. We studied two syngeneic primary cultures derived from a GBM with and without cells carrying DM, for their differential molecular and metabolic profiles, in vivo growth patterns, and re...
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