نتایج جستجو برای: oxygen glucose deprivation

تعداد نتایج: 408420  

2002
J. P. De La Cruz M. A. Villalobos M. A. Cuerda A. Guerrero J. A. González-Correa F. Sánchez De La Cuesta

We analyzed the effects of S-adenosyl-l-methionine (AdoMet) on tissue oxidative stress in rat brain slices exposed to reoxygenation after oxygen-glucose deprivation. The thiobarbituric acid reactive substances (TBARS), total and oxidized glutathione, and lactate-dehydrogenase efflux (LDH) from tissue to the incubation medium, were measured. Brain slices were incubated without glucose and with N...

Journal: :Anesthesiology 2000
R Almaas O D Saugstad D Pleasure T Rootwelt

BACKGROUND Barbiturates have been shown to be neuroprotective in several animal models, but the underlying mechanisms are unknown. In this study, the authors investigated the effect of barbiturates on free radical scavenging and attempted to correlate this with their neuroprotective effects in a model of hypoxic cell death in human NT2-N neurons. METHODS Hydroxyl radicals were generated by as...

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