C. S. WARD 1 has described previous devices used to indicate failure of oxygen supply. These include the '%osun" warning device, the Wantage oxygen failure alarm, 2 the Coote warning device, a the Adler and Burn device, 4 the "fail safe" oxygen device, 5 and the ECC gas failure alarm. 6 The reader is referred to Ward's paper for descriptions. It is evident from the above list that a warning sys...

There is a considerable discrepancy between oxygen supply and demand in the liver because hepatic oxygen consumption is relatively high but about 70% of the hepatic blood supply is poorly oxygenated portal vein blood derived from the gastrointestinal tract and spleen. Oxygen is delivered to hepatocytes by blood flowing from a terminal branch of the portal vein to a central venule via sinusoids,...

The retina has a uniquely high metabolic demand for oxygen that is normally met by a highly efficient vascular supply. Oxygen plays an essential role in oxidative phosphorylation as an electron acceptor in the mitochondrial respiratory chain in the synthesis of adenosine triphosphate required to support the metabolic demand, including that of the visual cycle. Maintenance of normal retinal func...