Near-infrared spectroscopy (NIRS) was utilized to gain insights into the kinetics of oxidative metabolism during exercise transitions. Ten untrained young men were tested on a cycle ergometer during transitions from unloaded pedaling to 5 min of constant-load exercise below (VT) the ventilatory threshold. Vastus lateralis oxygenation was determined by NIRS, and pulmonary O2 upta...

STUDY OBJECTIVES To assess the reliability of new and traditional oxygenation measurements in reflecting intrapulmonary shunt. DESIGN Prospective study. SETTING Cardiac surgery unit at a university hospital. PATIENTS Fifty-five patients undergoing coronary artery bypass grafting. MEASUREMENTS AND RESULTS Simultaneous blood samples were collected from an indwelling arterial line and a ca...

PURPOSE To examine differences in oxygenation kinetics in the nondominant and dominant flexor digitorum profundus (FDP) of rock climbers. METHODS Participants were 28 sport climbers with a range of on-site abilities (6a+ to 8a French Sport). Using near-infrared spectroscopy, oxygenation kinetics of the FDP was assessed by calculating the time to half recovery (t1/2 recovery) of the tissue-sat...

BACKGROUND Pleural effusions occur commonly after cardiac surgery and the effects of drainage on gas exchange in this population are not well established. We examined pulmonary function indices following drainage of pleural effusions in cardiac surgery patients. METHODS We performed a retrospective study examining the effects of pleural fluid drainage on the lung function indices of patients ...

BACKGROUND The alveolar recruitment maneuver (RM) has been reported to improve oxygenation in acute respiratory distress syndrome (ARDS) and may be related to reduced extravascular lung water (EVLW) in animals. This study was designed to investigate the effects of RM on EVLW in patients with ARDS. METHODS An open label, prospective, randomized controlled trial including patients with ARDS was...

Neurally adjusted ventilatory assist (NAVA) is an original approach to noninvasive ventilation that can improve patient-ventilator interaction and may infl uence physiologic outcomes 1 3 because the electrical activity of the diaphragm, a pneumatically independent signal, is used to control the timing and level of assist provided, regardless of the interface used. In a recent issue of CHEST (Ja...

Neurally adjusted ventilatory assist (NAVA) is an original approach to noninvasive ventilation that can improve patient-ventilator interaction and may infl uence physiologic outcomes 1 3 because the electrical activity of the diaphragm, a pneumatically independent signal, is used to control the timing and level of assist provided, regardless of the interface used. In a recent issue of CHEST (Ja...

Acute respiratory distress syndrome (ARDS) complicates nosocomial pneumonias (NPn) in 12% to 33% of patients with associated increases in mortality of up to 80%. A timely diagnosis of ARDS with NPn is, however, problematic. The aim of this investigation was to improve the diagnosis and treatment of the early stages of ARDS with NPn. A total of 82 cancer and multiple trauma patients were enrolle...

BACKGROUND Lung ischemia/reperfusion injury (LIRI) is a medical problem featuring pulmonary dysfunction and damage. The present study aimed to investigate the protective effects of erythropoietin (EPO), which has been reported to be an anti-inflammatory agent, on LIRI through inhibiting the TLR-4/NF-κB signaling pathway. MATERIAL AND METHODS All rats were randomly divided into 3 groups (n=8): a...

Background: Foot ulceration (DFU) is a serious complication of diabetes and new techniques that can predict wound healing may prove very helpful. We tested the ability of Medical Hyperspectral Technology (HT), a novel diagnostic scanning technique which can quantify tissue oxyand deoxyhemoglobin, to predict DFU healing. Methods: Ten T1DM patients with 21 foot ulcer sites, 13 T1DM without ulcers...