OBJECTIVES Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. MATERIALS AND METHODS In the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-a...

1. The contribution of dietary constituents to the large urinary output of benzoic acid characteristic of ruminants and some herbivores is not well understood. 2. Methods for the analysis of quinic, cyclohexanecarboxylic, benzoic, phenylacetic, 3-phenylpropionic and cinnamic acids in urine and in rumen fluids were developed. 3. The urinary output of aromatic acids by sheep given seven-rations w...

The question of the extent of the ability of the human organism to detoxicate benzoic acid by conjugation with glycocoll and elimination as hippuric acid in the urine has frequently been raised. Lewinsk? observed in the urine of men to whom 12 to 20 grams of benzoic acid had been given in small doses during t,he course of twelve hours, neither free benzoic acid nor benzoyl glycuronates. With la...

The infrared spectra of benzoic acid and deuterobenzoic acid embedded in Ar matrices were obtained. The only benzoic acid conformer with syn position of O-H and C=O groups was found to fix in the matrices. We have demonstrated that both a raise of benzoic acid concentration and a matrix annealing lead to formation of H-bonded benzoic acid dimers. The results of semiempirical AM1 calculations al...

A complement to the classic three-component Mannich reaction, the redox-Mannich reaction, utilizes the same starting materials but incorporates an isomerization step that enables the facile preparation of ring-substituted β-amino ketones. Reactions occur under relatively mild conditions and are facilitated by benzoic acid.

Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL-HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.

Ammonia-lyase activity for L-phenylalanine, m-hydroxyphenylalanine and L-tyrosine was demonstrated in cell-free extracts ofSporobolomyces roseus. Cultures of this organism converted DL-[ring-14C]phenylalanine and L-[U-14C]tyrosine into the corresponding cinnamic acid. Tracer studies showed that these compounds were further metabolized to [14C]protocatechuic acid. Benzoic acid andp-hydroxybenzoi...

Anaerobic sewage sludge was used to enrich a methanogenic m-cresol-degrading consortium. 6-Fluoro-3-methylphenol was synthesized and added to subcultures of the consortium with m-cresol. This caused the accumulation of 4-hydroxy-2-methylbenzoic acid. In a separate experiment, the addition of 3-fluorobenzoic acid caused the transient accumulation of 4-hydroxybenzoic acid. Inhibition with bromoet...