The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking the O-tosyl group had improved STAT-3 inhibitory activity. The equivalent potencies observed by the replacement of phosphonic acid moiety of 1...

m-Cresol metabolism under sulfate-reducing conditions was studied with a pure culture of Desulfotomaculum sp. strain Groll. Previous studies with a sulfate-reducing consortium indicated that m-cresol was degraded via an initial para-carboxylation reaction. However, 4-hydroxy-2-methylbenzoic acid was not degraded by strain Groll, and no evidence for ring carboxylation of m-cresol was found. Stra...

The dichloromethane and ethyl acetate extracts from the bark of Garcinia hombroniana yielded lupeol (1), lupeol acetate (2), 3β-acetoxylup-12,20(29)-diene (3), β-sitosterol (4), 22-dehydroclerosterol (5), mangiferolic acid (6), ursolic acid (7), betulin (8), betulinic acid (9), 1,3,6-trihydroxy-7-methoxy-2,8-(3-methyl2-butenyl)xanthone (10), leucodin (11), p-hydroxycinnamate (12), p-hydroxybenz...

Received 28 February 2012, Revised 05 April 2012, Accepted 11 June 2012 -------------------------------------------------------------------------------------------------------------------------------------------Abstract Fruits of Ziziphus mauritiana L. (ber) are consumed in fresh and dried/processed form in many countries across Asia including Pakistan. In the present study, we analyzed the com...

Today we are beginning to understand how phytochemicals can influence metabolism, cellular signaling and gene expression. The hydroxybenzoic acids are related to salicylic acid and salicin, the first compounds isolated that have a pharmacological activity. In this review we examine how a number of hydroxyphenolics have the potential to ameliorate cardiovascular problems related to aging such as...

Four new farnesyl hydroxybenzoic acid derivatives, kuhistanols E-H (1-4), were isolated from the roots of the Uzbekistan medicinal plant Ferula kuhistanica. The structures of the new compounds were elucidated based on spectroscopic and chemical evidence.